Lcat - lecithin cholesterol acyltransferase Gene

Also Known as D8Wsu61e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16816

Summary

Enables phosphatidylcholine-sterol O-acyltransferase activity and platelet-activating factor acetyltransferase activity. Involved in regulation of high-density lipoprotein particle assembly. Acts upstream of or within Cholesterol metabolic process and lipoprotein biosynthetic process. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and integumental system. Used to study Norum disease. Human ortholog(s) of this gene implicated in Norum disease and arteriosclerosis. Orthologous to human LCAT (lecithin-cholesterol Acyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Lcat Products (1)

mRNA Protein Name
NM_008490.2 NP_032516.2 phosphatidylcholine-sterol acyltransferase precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphatidylcholine-sterol O-acyltransferase activity IDA
IDA: Inferred from direct assay
9300780 MGI
enables platelet-activating factor acetyltransferase activity IDA
IDA: Inferred from direct assay
10393212 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cholesterol metabolic process IDA
IDA: Inferred from direct assay
9300780 MGI
acts upstream of or within lipoprotein biosynthetic process IDA
IDA: Inferred from direct assay
16245952 MGI
involved in regulation of high-density lipoprotein particle assembly IDA
IDA: Inferred from direct assay
19065001 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
10549415 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phosphatidylcholine-sterol acyltransferase

  • 1-alkyl-2-acetylglycerophosphocholine esterase

  • PAF acetylhydrolase

  • lecithin-cholesterol acyltransferase Lcat

  • phospholipid-cholesterol acyltransferase

  • platelet-activating factor acetylhydrolase

Recombinant Lcat Proteins

Cat. No. Product Name Accession Purity
HY-P77979 LCAT Protein, Mouse (HEK293, His) P16301 (F25-E438) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-113202S Stearoyl-L-carnitine-d3 Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-153169 6PPD-Q Inhibitor 99.77% Unkown
HY-P5282 ApoA-I mimetic peptide Activator 98.90% Unkown
HY-113202 Stearoylcarnitine Inhibitor 99.91% Unkown
HY-RS07549 LCAT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-113202S1 Stearoyl-L-carnitine-d9 chloride Inhibitor / Unkown
HY-186296 Cholestanol stearate Substrate / Unkown
HY-RS17454 Lcat Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23910 Lcat Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992256 Anti-LCAT Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lcat NCBI NCBI:3931