Ldha - lactate dehydrogenase A Gene

Also Known as Ldh1; Ldhm; l7R2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16828

Summary

The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the Lactate Dehydrogenase family. Mutations in this gene have been linked to hemolytic anemia and early postimplantation death in mice. Multiple transcript variants encoding different isoforms have been found for this gene. The mouse genome contains multiple pseudogenes of this gene. [provided by RefSeq, May 2013]

Ldha Products (2)

mRNA Protein Name
NM_001136069.2 NP_001129541.2 L-lactate dehydrogenase A chain isoform 2
NM_010699.2 NP_034829.1 L-lactate dehydrogenase A chain isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables L-lactate dehydrogenase activity IDA
IDA: Inferred from direct assay
7323947 MGI
enables L-lactate dehydrogenase activity IMP
IMP: Inferred from mutant phenotype
3796661 MGI
enables lactate dehydrogenase activity IMP
IMP: Inferred from mutant phenotype
8224816 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12107167 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within glucose catabolic process to lactate via pyruvate IMP
IMP: Inferred from mutant phenotype
8224816 MGI
involved in pyruvate catabolic process IDA
IDA: Inferred from direct assay
21041631 MGI
involved in pyruvate catabolic process IMP
IMP: Inferred from mutant phenotype
8224816 MGI
Cellular Component GO Annotation Evidence References Source
is active in cytosol IDA
IDA: Inferred from direct assay
17572440 MGI
located in cytosol IDA
IDA: Inferred from direct assay
11980919 MGI
located in sperm fibrous sheath IDA
IDA: Inferred from direct assay
16687649 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

L-lactate dehydrogenase A chain

  • LDH muscle subunit

  • LDH-M

  • M-LDH

  • lactate dehydrogenase 1, A chain

  • lactate dehydrogenase A4

Recombinant Ldha Proteins

Cat. No. Product Name Accession Purity
HY-P70259 LDHA Protein, Mouse (HEK293, His) P06151 (M1-F332) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73270 LDHA Protein, Mouse (His) P06151 (M1-F332) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100742A (R)-GNE-140 Inhibitor 99.77% Unkown
HY-100742 GNE-140 racemate Inhibitor 99.25% Unkown
HY-100742B (S)-GNE-140 Inhibitor 99.30% Unkown
HY-N4185 Licoflavone A Inhibitor 99.95% Unkown
HY-124113 4'-Bromo-resveratrol 99.94% Unkown
HY-118241 GNE-140 Inhibitor 98.43% Unkown
HY-16964 LDHA-IN-1 Inhibitor / Unkown
HY-175562 LDH-IN-4 Inhibitor / Unkown
HY-183858 NCATS-SM1440 Inhibitor / Unkown
HY-100742R GNE-140 racemate (Standard) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ldha NCBI NCBI:3939