Trak2 - trafficking kinesin protein 2 Gene

Also Known as GRIF-1; Als2cr3

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 171086

Summary

Enables several functions, including GABA Receptor binding activity; TPR domain binding activity; and Kinesin binding activity. Involved in several processes, including dendritic transport of mitochondrion; endosome to lysosome transport; and generation of neurons. Located in several cellular components, including axonal growth cone; dendrite; and neuronal cell body. Colocalizes with early endosome. Orthologous to human TRAK2 (trafficking Kinesin protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Trak2 Products (1)

mRNA	Protein	Name
NM_133560.2	NP_598244.2	trafficking kinesin-binding protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GABA receptor binding	IDA IDA: Inferred from direct assay	12034717	RGD
enables GABA receptor binding	IMP IMP: Inferred from mutant phenotype	12034717	RGD
enables TPR domain binding	IDA IDA: Inferred from direct assay	12435728	RGD
enables enzyme binding	IPI IPI: Inferred from physical interaction	12435728	RGD
enables kinesin binding	IDA IDA: Inferred from direct assay	15644324	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12435728	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	12034717	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	23395375	RGD
involved in dendritic transport of mitochondrion	IMP IMP: Inferred from mutant phenotype	23395375	RGD
involved in endosome to lysosome transport	IDA IDA: Inferred from direct assay	17062640	RGD
involved in negative regulation of axonogenesis	IMP IMP: Inferred from mutant phenotype	23395375	RGD
involved in protein O-linked glycosylation	IDA IDA: Inferred from direct assay	12435728	RGD
involved in protein targeting	IDA IDA: Inferred from direct assay	12435728	RGD
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12435728	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in axonal growth cone	IDA IDA: Inferred from direct assay	25653102	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	12034717	RGD
located in dendrite	IDA IDA: Inferred from direct assay	25653102	RGD
located in early endosome	IDA IDA: Inferred from direct assay	17062640	RGD
located in mitochondrion	IDA IDA: Inferred from direct assay	19528298	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	25653102	RGD
located in nucleus	IDA IDA: Inferred from direct assay	12034717	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	12034717	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
trafficking kinesin-binding protein 2	GABA-A receptor interacting factor-1 O-GlcNAc transferase-interacting protein of 98 kDa amyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 3 amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 3 homolog amyotrop

Trak2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Trak2	Q8R2H7	KIF5A	Homo sapiens	Q12840	Anti Tag CoIP	24161670

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14980	TRAK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21794	Trak2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28310	Trak2 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Trak2	NCBI	NCBI:66008