Trpm8 - transient receptor potential cation channel, subfamily M, member 8 Gene

Also Known as CMR1; TRPP8; LTRPC6; Trp-p8; LTrpC-6

Species: Mus musculus

Gene Type: protein coding
Gene ID: 171382

Summary

Enables Calcium Channel activity and identical protein binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including cellular calcium ion homeostasis; response to cold; and thermoception. Located in external side of plasma membrane. Is expressed in dorsal root ganglion; inferior vagus ganglion; and vagus ganglion. Orthologous to human TRPM8 (transient receptor potential cation channel subfamily M member 8). [provided by Alliance of Genome Resources, Apr 2022]

Trpm8 Products (1)

mRNA Protein Name
NM_134252.5 NP_599013.1 transient receptor potential cation channel subfamily M member 8

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium channel activity IDA
IDA: Inferred from direct assay
11893340 MGI
enables calcium channel activity IMP
IMP: Inferred from mutant phenotype
17538622 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
17015441 MGI
enables monoatomic ion channel activity IDA
IDA: Inferred from direct assay
11893340 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18455988 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within calcium ion transport IDA
IDA: Inferred from direct assay
17015441 MGI
acts upstream of or within intracellular calcium ion homeostasis IDA
IDA: Inferred from direct assay
11893340 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
22241835 MGI
acts upstream of or within response to cold IDA
IDA: Inferred from direct assay
12654248 MGI
acts upstream of or within response to cold IMP
IMP: Inferred from mutant phenotype
17481391 MGI
acts upstream of or within response to temperature stimulus IDA
IDA: Inferred from direct assay
11893340 MGI
acts upstream of or within thermoception IDA
IDA: Inferred from direct assay
12654248 MGI
acts upstream of or within thermoception IMP
IMP: Inferred from mutant phenotype
17481391 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
17015441 MGI
located in membrane IDA
IDA: Inferred from direct assay
11893340 MGI
located in membrane raft IDA
IDA: Inferred from direct assay
19176480 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transient receptor potential cation channel subfamily M member 8

  • TRP ion channel TRPM8

  • long transient receptor potential channel 6

  • transient receptor potential p8

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108449 Acoltremon Agonist 99.13% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-109087 Elismetrep Antagonist 99.59% Phase 2
HY-115506 PF-05105679 Antagonist 99.88% Phase 1

Pre-clinical Phase

Bioactive Molecules (19)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-11062 Icilin Agonist 99.26% Unkown
HY-18662 RQ-00203078 Antagonist 99.84% Unkown
HY-19976 RN-1747 Modulator 99.27% Unkown
HY-110181 M8-B Antagonist 99.74% Unkown
HY-144372 TRPV1 antagonist 3 Antagonist 99.30% Unkown
HY-N7144A Citronellyl acetate 98.0% Unkown
HY-N7117 1,4-Cineole Activator 95.0% Unkown
HY-108461 TRPM8-IN-1 Inhibitor 99.44% Unkown
HY-172774 TRPV1 antagonist 10 Antagonist 98.54% Unkown
HY-141712 ZA18 Inhibitor 99.72% Unkown
HY-170302 CMP233 Inhibitor 99.10% Unkown
HY-W014394 Vanillyl butyl ether Agonist 99.75% Unkown
HY-174825 TRPM8 antagonist 4 Antagonist / Unkown
HY-168471 AAL-149 Inhibitor / Unkown
HY-179432 Cannabitwinol Modulator / Unkown
HY-174846 TRPM8 antagonist 4 prodrug Antagonist / Unkown
HY-177763 TRPM8 receptor agonist-1 Agonist / Unkown
HY-117372 DFL23448 Antagonist / Unkown
HY-185173 (E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trpm8 NCBI NCBI:79054