Trpm8 - transient receptor potential cation channel, subfamily M, member 8 Gene

Also Known as CMR1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 171384

Summary

Enables ion channel activity. Involved in response to cold. Predicted to be located in external side of plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human TRPM8 (transient receptor potential cation channel subfamily M member 8). [provided by Alliance of Genome Resources, Apr 2022]

Trpm8 Products (1)

mRNA Protein Name
NM_134371.3 NP_599198.2 transient receptor potential cation channel subfamily M member 8

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IDA
IDA: Inferred from direct assay
20214891 RGD
enables monoatomic ion channel activity IDA
IDA: Inferred from direct assay
11882888 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
22750945 RGD
Biological Process GO Annotation Evidence References Source
involved in calcium ion transmembrane transport IDA
IDA: Inferred from direct assay
11882888 RGD
involved in response to cold IDA
IDA: Inferred from direct assay
11882888 RGD
Cellular Component GO Annotation Evidence References Source
located in plasma membrane raft IDA
IDA: Inferred from direct assay
19176480 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transient receptor potential cation channel subfamily M member 8

  • cold menthol receptor 1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108449 Acoltremon Agonist 99.13% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-109087 Elismetrep Antagonist 99.59% Phase 2
HY-115506 PF-05105679 Antagonist 99.88% Phase 1

Pre-clinical Phase

Bioactive Molecules (19)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-11062 Icilin Agonist 99.26% Unkown
HY-18662 RQ-00203078 Antagonist 99.84% Unkown
HY-19976 RN-1747 Modulator 99.27% Unkown
HY-110181 M8-B Antagonist 99.74% Unkown
HY-144372 TRPV1 antagonist 3 Antagonist 99.30% Unkown
HY-N7144A Citronellyl acetate 98.0% Unkown
HY-N7117 1,4-Cineole Activator 95.0% Unkown
HY-108461 TRPM8-IN-1 Inhibitor 99.44% Unkown
HY-172774 TRPV1 antagonist 10 Antagonist 98.54% Unkown
HY-141712 ZA18 Inhibitor 99.72% Unkown
HY-170302 CMP233 Inhibitor 99.10% Unkown
HY-W014394 Vanillyl butyl ether Agonist 99.75% Unkown
HY-174825 TRPM8 antagonist 4 Antagonist / Unkown
HY-168471 AAL-149 Inhibitor / Unkown
HY-179432 Cannabitwinol Modulator / Unkown
HY-174846 TRPM8 antagonist 4 prodrug Antagonist / Unkown
HY-177763 TRPM8 receptor agonist-1 Agonist / Unkown
HY-117372 DFL23448 Antagonist / Unkown
HY-185173 (E)-3-Benzo[1,3]dioxol-5-yl-N,N-diphenyl-2-propenamide / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trpm8 NCBI NCBI:79054