Akr1c3 - aldo-keto reductase family 1, member C3 Gene

Also Known as Akr1c18

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 171516

Summary

Enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity and alditol:NADP+ 1-oxidoreductase activity. Involved in several processes, including cellular response to hormone stimulus; cellular response to ketone; and female pregnancy. Acts upstream of or within progesterone metabolic process. Located in cytosol and nucleus. Biomarker of polycystic ovary syndrome and pre-eclampsia. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to human AKR1C3 (aldo-keto reductase family 1 member C3). [provided by Alliance of Genome Resources, Apr 2022]

Akr1c3 Products (1)

mRNA Protein Name
NM_138510.2 NP_612519.1 aldo-keto reductase family 1 member C18

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity IDA
IDA: Inferred from direct assay
4392955 RGD
enables aldo-keto reductase (NADPH) activity IDA
IDA: Inferred from direct assay
8977402 RGD
enables aldose reductase (NADPH) activity IDA
IDA: Inferred from direct assay
8977402 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to follicle-stimulating hormone stimulus IEP
IEP: Inferred from expression pattern
2994767 RGD
involved in cellular response to forskolin IEP
IEP: Inferred from expression pattern
9731216 RGD
involved in cellular response to gonadotropin-releasing hormone IEP
IEP: Inferred from expression pattern
6778878 RGD
involved in cellular response to prolactin IEP
IEP: Inferred from expression pattern
2401226 RGD
involved in cellular response to testosterone stimulus IEP
IEP: Inferred from expression pattern
2994767 RGD
involved in cellular response to transforming growth factor beta stimulus IMP
IMP: Inferred from mutant phenotype
2401226 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
9202232 RGD
acts upstream of or within progesterone metabolic process IDA
IDA: Inferred from direct assay
8172618 RGD
involved in progesterone metabolic process IDA
IDA: Inferred from direct assay
4392955 RGD
involved in regulation of steroid biosynthetic process IDA
IDA: Inferred from direct assay
4392955 RGD
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
8194472 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aldo-keto reductase family 1 member C18

  • 20-alpha-HSD

  • 20-alpha-hydroxysteroid dehydrogenase

  • 20alpha-hydroxysteroid dehydrogenase

  • HSD1

  • aldo-keto reductase family 1, member C18

  • aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-19903 ASP-9521 98.0% Phase 2
HY-124573 (R)-Odafosfamide 98.52% Phase 2
HY-149040 Odafosfamide 99.06% Phase 2
HY-156701 BAY-1128688 / Phase 2

Pre-clinical Phase

Bioactive Molecules (51)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0376 Liquiritin 99.99% Unkown
HY-150644 S07-2010 98.35% Unkown
HY-107379 AKR1C3-IN-1 98.21% Unkown
HY-138557 AKR1C3-IN-4 99.77% Unkown
HY-152189 S19-1035 99.93% Unkown
HY-W008567 N-Deschlorobenzoyl indomethacin 95.0% Unkown
HY-N10361 Drupanin 99.35% Unkown
HY-109154 Obafistat Inhibitor 99.92% Unkown
HY-155035 S07-1066 99.48% Unkown
HY-D1342 Coumberol 99.99% Unkown
HY-152188 AKR1C3-IN-9 99.77% Unkown
HY-172314 ACHM-025 98.06% Unkown
HY-W414731 N-(3-Methylphenyl)anthranilic acid 99.82% Unkown
HY-163940 LX1 99.13% Unkown
HY-171115 Pyrone-211 99.32% Unkown
HY-116170 SN34037 Inhibitor 99.02% Unkown
HY-176084 RJG-2051 99.42% Unkown
HY-W024692 Indomethacin methylester 99.92% Unkown
HY-19903R ASP-9521 (Standard) 94.47% Unkown
HY-W069545 (S)-1-Tetralol 99.75% Unkown
HY-121656 AKR1C2/3-IN-2 Inhibitor / Unkown
HY-123732 CRT0083914 / Unkown
HY-144749 AKR1C3-IN-5 / Unkown
HY-146573 AKR1C3-IN-6 / Unkown
HY-146574 AKR1C3-IN-7 / Unkown
HY-146575 AKR1C3-IN-8 / Unkown
HY-150646 S07-2009 / Unkown
HY-150648 S07-2008 / Unkown
HY-150649 S07-2005 (racemic) / Unkown
HY-150650 S07-2001 / Unkown
HY-155502 AKR1C3-IN-10 / Unkown
HY-157810 AKR1C3-IN-11 / Unkown
HY-161839 AKR1C2/3-IN-1 / Unkown
HY-163323 AKR1C3-IN-12 / Unkown
HY-163609 PROTAC AKR1C3 degrader-1 Degrader / Unkown
HY-163610 AKR1C3-IN-13 / Unkown
HY-163784 AKR1C3-IN-14 / Unkown
HY-173132 AKR1Cs-IN-1 / Unkown
HY-173453 AKR1C3-IN-15 / Unkown
HY-180562 KARS-IN-1 Inhibitor / Unkown
HY-181542 SG-55 / Unkown
HY-184699 AKR1C3-IN-16 Inhibitor / Unkown
HY-184927 S34-1035 Inhibitor / Unkown
HY-184928 S34-1040 Inhibitor / Unkown
HY-187527 AKR1C3-IN-17 / Unkown
HY-N0376R Liquiritin (Standard) / Unkown
HY-RS00536 AKR1C3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W706737 N-Deschlorobenzoyl indomethacin-d3 / Unkown
HY-124432 CRT0093964 Inhibitor / Unkown
HY-163647 Lenalidomide-COCH-PEG2-azido / Unkown
HY-RS23044 Akr1c3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Akr1c3 NCBI NCBI:8644