2. Gene
  3. Mapkapk2 - MAP kinase-activated protein kinase 2 Gene

Mapkapk2 - MAP kinase-activated protein kinase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as MK2; MK-2; Rps6kc1; MAPKAP-K2

Gene ID: 17164 | Gene type: protein coding

About Mapkapk2

Chromosome 1: 130,981,437-131,025,563 reverse strand.GRCm39:CM000994.3

This gene has 2 transcripts (splice variants), 238 orthologues, 6 paralogues and is associated with 33 phenotypes. Ubiquitous expression in heart adult (RPKM 82.3), adrenal adult (RPKM 65.) and 28 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in several processes, including macropinocytosis; regulation of cytokine production; and response to lipopolysaccharide. Acts upstream of or within inner ear development; p38MAPK cascade; and positive regulation of gene expression. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and immune system. Orthologous to human MAPKAPK2 (MAPK activated protein kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Mapkapk2 Products(1)

mRNA Protein Name
NM_008551.2 NP_032577.1 MAP kinase-activated protein kinase 2

Mapkapk2 Protein Structure

STKc_MAPKAPK2

STKc_MAPKAPK2: cd14170 (46 - 348)

  • 0
  • 100
  • 200
  • 300
  • 386 a.a.
Protein Preferred Names Protein Names

MAP kinase-activated protein kinase 2

MAPK-activated protein kinase 2

MAPKAP kinase 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12834A MK2-IN-1 hydrochloride Inhibitor 98.96% Unkown
HY-107427 PF-3644022 Inhibitor 99.65% Unkown
HY-131249 MK2-IN-3 Inhibitor 99.58% Unkown
HY-148061 DB1113 99.28% Unkown
HY-112457 MK2-IN-3 hydrate Inhibitor ≥99.0% Unkown
HY-12834 MK2-IN-1 Inhibitor / Unkown
HY-147283 MK2-IN-4 Inhibitor / Unkown
HY-RS08131 MAPKAPK2 Human Pre-designed siRNA Set A / Unkown
HY-RS08132 Mapkapk2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08133 Mapkapk2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mapkapk2 NCBI NCBI:9261