Mapkapk2 - MAP kinase-activated protein kinase 2 Gene

Also Known as MK2; MK-2; Rps6kc1; MAPKAP-K2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17164

About Mapkapk2

Chromosome 1: 130,981,437-131,025,563 reverse strand.GRCm39:CM000994.3

This gene has 2 transcripts (splice variants), 238 orthologues, 6 paralogues and is associated with 33 phenotypes. Ubiquitous expression in heart adult (RPKM 82.3), adrenal adult (RPKM 65.) and 28 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in several processes, including macropinocytosis; regulation of cytokine production; and response to lipopolysaccharide. Acts upstream of or within inner ear development; p38MAPK cascade; and positive regulation of gene expression. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and immune system. Orthologous to human MAPKAPK2 (MAPK activated protein kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Mapkapk2 Products (1)

mRNA Protein Name
NM_008551.2 NP_032577.1 MAP kinase-activated protein kinase 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17906627 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
9628873 MGI
Biological Process GO Annotation Evidence References Source
involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
10559880 MGI
acts upstream of or within inner ear development IDA
IDA: Inferred from direct assay
21795542 MGI
acts upstream of or within mRNA stabilization IMP
IMP: Inferred from mutant phenotype
11741878 MGI
acts upstream of macrophage cytokine production IMP
IMP: Inferred from mutant phenotype
24020373 MGI
involved in macropinocytosis IMP
IMP: Inferred from mutant phenotype
17906627 MGI
acts upstream of or within p38MAPK cascade IMP
IMP: Inferred from mutant phenotype
24020373 MGI
acts upstream of or within positive regulation of macrophage cytokine production IMP
IMP: Inferred from mutant phenotype
24020373 MGI
acts upstream of or within positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
24020373 MGI
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
9628873 MGI
involved in regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
10559880 MGI
involved in regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
10559880 MGI
involved in response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
10559880 MGI
involved in toll-like receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17906627 MGI
acts upstream of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
24020373 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
9628873 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9628873 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mapkapk2 Protein Structure

STKc_MAPKAPK2

STKc_MAPKAPK2: cd14170 (46 - 348)

  • 0
  • 100
  • 200
  • 300
  • 386 a.a.
Protein Preferred Names Protein Names

MAP kinase-activated protein kinase 2

  • MAPK-activated protein kinase 2

  • MAPKAP kinase 2

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-16129 CBP-501 Inhibitor 99.75% Phase 2
HY-16129A CBP-501 acetate Inhibitor 99.75% Phase 2

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-107427 PF-3644022 Inhibitor 99.91% Unkown
HY-131249 MK2-IN-3 Inhibitor 99.15% Unkown
HY-12834A MK2-IN-1 hydrochloride Inhibitor 98.36% Unkown
HY-112457 MK2-IN-3 hydrate Inhibitor 99.08% Unkown
HY-148061 DB1113 99.86% Unkown
HY-12834 MK2-IN-1 Inhibitor 99.04% Unkown
HY-148063 DB0614 99.92% Unkown
HY-147283 MK2-IN-4 Inhibitor / Unkown
HY-175809 SRT6 Inhibitor / Unkown
HY-182596 INHIB1X Inhibitor / Unkown
HY-P10367 Ziptide / Unkown
HY-RS08131 MAPKAPK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08132 Mapkapk2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08133 Mapkapk2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mapkapk2 NCBI NCBI:9261