Mc1r - melanocortin 1 receptor Gene

Also Known as e; Tob; Mcr1; Mshra

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17199

About Mc1r

Chromosome 8: 124,133,846-124,137,483 forward strand.GRCm39:CM001001.3

This gene has 1 transcript (splice variant), 156 orthologues, 18 paralogues and is associated with 20 phenotypes.

Summary

Enables melanocyte-stimulating hormone receptor activity. Involved in intracellular signal transduction; positive regulation of intracellular signal transduction; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within melanin biosynthetic process; pigmentation; and sensory perception of pain. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in ductus deferens; epididymis; esophagus; and skin. Human ortholog(s) of this gene implicated in familial melanoma; major depressive disorder; melanoma; oculocutaneous albinism type II; and pigmentation disease. Orthologous to human MC1R (melanocortin 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Mc1r Products (1)

mRNA Protein Name
NM_008559.3 NP_032585.2 melanocyte-stimulating hormone receptor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables melanocortin receptor activity IDA
IDA: Inferred from direct assay
18292087 MGI
enables melanocyte-stimulating hormone receptor activity IDA
IDA: Inferred from direct assay
9454589 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9454589 MGI
Biological Process GO Annotation Evidence References Source
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
18292087 MGI
acts upstream of or within melanin biosynthetic process IMP
IMP: Inferred from mutant phenotype
7665913 MGI
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
18292087 MGI
involved in positive regulation of cAMP/PKA signal transduction IDA
IDA: Inferred from direct assay
18292087 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18292087 MGI
acts upstream of or within sensory perception of pain IMP
IMP: Inferred from mutant phenotype
12663858 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mc1r Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (36 - 306)

7tm_GPCRs

7tm_GPCRs: cd14964 (38 - 62)

7tm_GPCRs

7tm_GPCRs: cd14964 (71 - 93)

7tm_GPCRs

7tm_GPCRs: cd14964 (115 - 137)

7tm_GPCRs

7tm_GPCRs: cd14964 (160 - 176)

7tm_GPCRs

7tm_GPCRs: cd14964 (182 - 205)

7tm_GPCRs

7tm_GPCRs: cd14964 (237 - 259)

7tm_GPCRs

7tm_GPCRs: cd14964 (274 - 299)

  • 0
  • 100
  • 200
  • 300
  • 315 a.a.
Protein Preferred Names Protein Names

melanocyte-stimulating hormone receptor

  • MC1-R

  • MSH-R

  • extension recessive yellow

  • melanocortin receptor 1

  • tobacco darkening

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N2466 Melanotan I Agonist 99.04% Unkown
HY-N2466A Melanotan I acetate Agonist 98.96% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-107139 JNJ-10229570 Antagonist 98.0% Phase 2

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1726 MSG606 Antagonist 99.68% Unkown
HY-115644 BMS-470539 dihydrochloride Agonist 99.85% Unkown
HY-P0097A Nonapeptide-1 acetate salt Antagonist 95.58% Unkown
HY-P5247 Palmitoyl tetrapeptide-20 Activator 99.21% Unkown
HY-P0097 Nonapeptide-1 Antagonist 98.74% Unkown
HY-147301 Resomelagon Agonist 98.79% Unkown
HY-P1545A ACTH (1-17) TFA Agonist 99.79% Unkown
HY-P2336A CCZ01048 TFA 98.54% Unkown
HY-19870C Setmelanotide monoacetate Agonist 99.81% Unkown
HY-P5247A Palmitoyl tetrapeptide-20 TFA Activator / Unkown
HY-P99004 hMC1R agonist 1 Antagonist / Unkown
HY-168383 (E/Z)-Resomelagon acetate Agonist / Unkown
HY-P1726A MSG606 TFA Antagonist / Unkown
HY-111131 RY764 Agonist / Unkown
HY-125055A CD08108 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mc1r NCBI NCBI:4157