DLX2 - distal-less homeobox 2 Gene

Also Known as TES1; TES-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1746

About DLX2

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:172,099,438-172,102,900 (from NCBI)

This gene has 2 transcripts (splice variants), 227 orthologues and 9 paralogues. Low expression observed in reference dataset.

Summary

Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2. [provided by RefSeq, Jul 2008]

DLX2 Products (1)

mRNA	Protein	Name
NM_004405.4	NP_004396.1	homeobox protein DLX-2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DLX2 Protein Structure

DLL_N

Homeobox

0
100
200
300
328 a.a.

Protein Preferred Names	Protein Names
homeobox protein DLX-2	distal-less homeo box 2

DLX2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DLX2	Q07687	GRN	Homo sapiens	P28799	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

DLX2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811354	DLX2 Antibody	WB, IHC-P	Human
HY-P86853	Dlx2 Antibody (YA6546)	IHC-P	Mouse, Rat

Related Diseases

Diseases	Alias
Tooth Agenesis	Oligodontia Hypodontia Selective Tooth Agenesis Tooth Agenesis, Selective Familial Tooth Agenesis Anodontia Congenital Absence Of One Tooth
Trichodentoosseous Syndrome	Tricho-Dento-Osseous Syndrome Tdo Syndrome Trichodontoosseous Syndrome TDO Enamel Hypoplasia And Hypocalcification With Associated Strikingly Curly Hair
Syngnathia	Cleft Palate-Lateral Synechia Syndrome Cpls Syndrome Cleft Palate Lateral Synechia Syndrome
Ectodermal Dysplasia	Congenital Ectodermal Defect Congenital Ectodermal Dysplasia Ectodermal Dysplasia Syndrome Dysplasia, Ectodermal
Split Hand-Foot Malformation	Ectrodactyly Split-Hand/Foot Malformation Lobster-Claw Deformity Split-Hand Deformity Split Hand Foot Malformation Shfm Split Hand Foot Deformity Split Hand Foot Deformity 1
Axenfeld-Rieger Syndrome	Axenfeld Syndrome Rieger Syndrome Rieger Anomaly Axenfeld Anomaly Anomaly, Rieger'S Hagedoom Syndrome Rgs - Rieger Syndrome Rieger'S Anomaly Goniodysgenesis Hypodontia Iridogoniodysgenesis With Somatic Anomalies Ars Axenfeld And Rieger Anomaly Axra Axrs Rieger Eye Malformation Sequence
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Orofacial Cleft	Cleft, Orofacial
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03813	DLX2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17742	Dlx2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24208	Dlx2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DLX2	MGD	MGI:94902
Rattus norvegicus	DLX2	RGD	RGD:1304853
Canis familiaris	DLX2	VGNC	VGNC:39990
Bos taurus	DLX2	VGNC	VGNC:28099
Macaca mulatta	DLX2	VGNC	VGNC:104522
Felis catus	DLX2	VGNC	VGNC:80181
Others	DLX2	NCBI