Msc - musculin Gene

Also Known as MyoR; bHLHa22

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17681

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II; roof of mouth development; and skeletal muscle organ development. Acts upstream of or within cellular response to Leukemia Inhibitory Factor. Located in nucleus. Is expressed in several structures, including branchial arch; foregut; limb bud; musculature; and trunk mesenchyme. Orthologous to human MSC (musculin). [provided by Alliance of Genome Resources, Apr 2022]

Msc Products (5)

mRNA Protein Name
NM_001360810.2 NP_001347739.1 musculin isoform 2
NM_001411711.1 NP_001398640.1 musculin isoform 3
NM_001411712.1 NP_001398641.1 musculin isoform 4
NM_001411713.1 NP_001398642.1 musculin isoform 5
NM_010827.3 NP_034957.1 musculin isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
9892671 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
9892671 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
9892671 MGI
Biological Process GO Annotation Evidence Referencias Source
involved in branchiomeric skeletal muscle development IGI
IGI: Inferred from genetic interaction
12493912 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
involved in diaphragm development IGI
IGI: Inferred from genetic interaction
12493912 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9892671 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
9892671 MGI
involved in roof of mouth development IGI
IGI: Inferred from genetic interaction
12493912 MGI
Cellular Component GO Annotation Evidence Referencias Source
located in nucleus IDA
IDA: Inferred from direct assay
19796622 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

musculin

  • myogenic repressor

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Referencia número Nombre del producto Efecto
Pureza Phase
HY-101215 Evobrutinib Inhibitor 99.60% Phase 3
HY-12042 Pimasertib Inhibitor 99.60% Phase 2
HY-135827 Roginolisib Inhibitor 99.66% Phase 2
HY-100501 M2698 Inhibitor 99.74% Phase 1
Inhibitory Antibodies (1)
Referencia número Nombre del producto Efecto
Pureza Phase
HY-P990461 Anti-LIF Antibody (MSC-1) Inhibitor 98.51% Phase 1

Pre-clinical Phase

Bioactive Molecules (43)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-P1410 GsMTx4 Inhibitor 99.89% Unkown
HY-P1410A GsMTx4 TFA Inhibitor 99.85% Unkown
HY-P1410B D-GsMTx4 Inhibitor 99.44% Unkown
HY-123872 MSC1094308 Inhibitor 99.89% Unkown
HY-132301 MSC-4381 Inhibitor 98.89% Unkown
HY-P1410C D-GsMTx4 TFA Inhibitor 99.89% Unkown
HY-101611 MSC2530818 Inhibitor 99.62% Unkown
HY-148518 MSC-1186 Inhibitor 98.95% Unkown
HY-108628 SU16f Inhibitor 99.36% Unkown
HY-N0898A (-)-Catechin Inhibitor 98.83% Unkown
HY-B1890 (±)-Catechin Inhibitor 99.51% Unkown
HY-123851 MSC2504877 Inhibitor 99.25% Unkown
HY-110218 CW 008 Agonist 98.15% Unkown
HY-147208 MSC-4106 Inhibitor 99.87% Unkown
HY-177512 MSC778 Inhibitor / Unkown
HY-165607S MCB-22-174 99.78% Unkown
HY-101611R MSC2530818 (Standard) Inhibitor 99.16% Unkown
HY-126225 SJA710-6 99.62% Unkown
HY-160053 Gint4.T aptamer sodium Chemical 94.50% Unkown
HY-135827A Roginolisib hemifumarate Inhibitor 99.80% Unkown
HY-131032 KI-7 Agonist 99.16% Unkown
HY-169332 Piezo1 agonist 1-d2 / Unkown
HY-108438 TCS 2210 Inducer / Unkown
HY-110262 MSC 2032964A Inhibitor / Unkown
HY-113568 CAY10581 Inhibitor / Unkown
HY-12042A Pimasertib hydrochloride Inhibitor / Unkown
HY-147511 PPARγ agonist 7 Agonist / Unkown
HY-168506 MSC-1254 Inhibitor / Unkown
HY-170581 PPARγ/δ modulator 2 Modulator / Unkown
HY-170837 STAT5-IN-3 Inhibitor / Unkown
HY-B1890S (±)-Catechin-13C3 Inhibitor / Unkown
HY-N0008R Orcinol glucoside (Standard) / Unkown
HY-N8917 (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane Activator / Unkown
HY-P11346 N-Cadherin mimic peptide Agonist / Unkown
HY-P4125 FITC-LC-TAT (47-57) / Unkown
HY-RS08707 MSC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13119 SLC25A37 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-153332 Tankyrase-IN-5 Inhibitor / Unkown
HY-168505 MSC-5046 Inhibitor / Unkown
HY-177058 DSP30 Agonist 95.27% Unkown
HY-N2457 Laxogenin Inhibitor / Unkown
HY-RS17017 Msc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23460 Msc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Msc NCBI NCBI:9242