2. Gene
  3. MSC - musculin Gene

MSC - musculin Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ABF1; MYOR; ABF-1; bHLHa22

Gene ID: 9242 | Gene type: protein coding

About MSC

Cytogenetic location: 8q13.3 Genomic coordinates (GRCh38): 8:71,841,560-71,844,412 (from NCBI)

This gene has 3 transcripts (splice variants), 214 orthologues and 13 paralogues. Broad expression in placenta (RPKM 12.2), gall bladder (RPKM 7.2) and 23 other tissues.

Summary

The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway. [provided by RefSeq, Jul 2008]

MSC Products(1)

mRNA Protein Name
NM_005098.4 NP_005089.2 musculin

MSC Protein Structure

HLH

HLH: Helix-loop-helix DNA-binding domain (108 - 160)

  • 0
  • 100
  • 206 a.a.
Protein Preferred Names Protein Names

musculin

activated B-cell factor 1, homolog of mouse musculin

Related Diseases

Diseases Alias
Ichthyosis, Congenital, Autosomal Recessive 3

Autosomal Recessive Congenital Ichthyosis 3

ARCI3

Lamellar Ichthyosis 5

Collodion Baby, Self-Healing

Ichthyosis, Lamellar, 5, Formerly

Li5, Formerly

Li5

Self-Healing Collodion Baby

Ichthyosis, Congenital, Autosomal Recessive, Type 3
Rhabdomyosarcoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-12042 Pimasertib Inhibitor 99.88% Phase 2
HY-100501 M2698 Inhibitor 99.87% Phase 1
Pre-clinical Phase
Bioactive Molecules (26)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P1410 GsMTx4 Inhibitor 99.80% Unkown
HY-P1410A GsMTx4 TFA Inhibitor 99.38% Unkown
HY-123872 MSC1094308 Inhibitor 99.89% Unkown
HY-101611 MSC2530818 Inhibitor 99.67% Unkown
HY-147208 MSC-4106 Inhibitor 99.82% Unkown
HY-132301 MSC-4381 Inhibitor 98.11% Unkown
HY-N0898A (-)-Catechin Inhibitor 98.78% Unkown
HY-P1410C D-GsMTx4 TFA Inhibitor 99.43% Unkown
HY-148518 MSC-1186 Inhibitor 99.42% Unkown
HY-N0008 Orcinol glucoside 99.57% Unkown
HY-135827 Roginolisib Inhibitor 99.89% Unkown
HY-B1890 (±)-Catechin Inhibitor 98.38% Unkown
HY-110218 CW 008 Agonist 98.15% Unkown
HY-101215 Evobrutinib 98.60% Yes
HY-123851 MSC2504877 Inhibitor 98.50% Unkown
HY-135827A Roginolisib hemifumarate Inhibitor 99.95% Unkown
HY-131032 KI-7 Agonist 99.16% Unkown
HY-108438 TCS 2210 / Unkown
HY-110262 MSC 2032964A Inhibitor / Unkown
HY-113568 CAY10581 Inhibitor / Unkown
HY-147511 PPARγ agonist 7 Agonist / Unkown
HY-160053 Gint4.T aptamer sodium Chemical / Unkown
HY-N8917 (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane Activator / Unkown
HY-P1410B D-GsMTx4 Inhibitor / Unkown
HY-RS08707 MSC Human Pre-designed siRNA Set A / Unkown
HY-153332 Tankyrase-IN-5 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MSC VGNC VGNC:43436
Rattus norvegicus MSC RGD RGD:1305496
Bos taurus MSC VGNC VGNC:31691
Macaca mulatta MSC VGNC VGNC:74930
Mus musculus MSC MGD MGI:1333884
Others MSC NCBI