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MSC - musculin Gene

Also Known as ABF1; MYOR; ABF-1; bHLHa22

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9242

About MSC

Cytogenetic location: 8q13.3 Genomic coordinates (GRCh38): 8:71,841,560-71,844,412 (from NCBI)

This gene has 3 transcripts (splice variants), 214 orthologues and 13 paralogues. Broad expression in placenta (RPKM 12.2), gall bladder (RPKM 7.2) and 23 other tissues.

Summary

The protein encoded by this gene is a transcriptional repressor capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro. The encoded protein also forms heterodimers with E2A proteins in vivo. This protein is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. This gene is a downstream target of the B-cell receptor signal transduction pathway. [provided by RefSeq, Jul 2008]

MSC Products (1)

mRNA	Protein	Name
NM_005098.4	NP_005089.2	musculin

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9584154	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MSC Protein Structure

HLH

0
100
206 a.a.

Protein Preferred Names	Protein Names
musculin	activated B-cell factor 1, homolog of mouse musculin

MSC Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MSC	O60682	TCF12	Homo sapiens	Q99081-3	Validated Y2H	32296183
Intra	MSC	O60682	TCF12	Homo sapiens	Q99081-3	Y2H Array	32296183
Intra	MSC	O60682	TCF12	Homo sapiens	Q99081-3	Y2H Prey Pooling	32296183
Intra	MSC	O60682	TCF4	Homo sapiens	P15884-3	Validated Y2H	32296183
Intra	MSC	O60682	TCF4	Homo sapiens	P15884-3	Y2H Array	32296183
Intra	MSC	O60682	TCF4	Homo sapiens	P15884-3	Y2H Prey Pooling	32296183
Intra	MSC	O60682	PBX2	Homo sapiens	P40425	Validated Y2H	32296183
Intra	MSC	O60682	PBX2	Homo sapiens	P40425	Y2H Array	32296183
Intra	MSC	O60682	PBX2	Homo sapiens	P40425	Y2H Prey Pooling	32296183
Intra	MSC	O60682	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
Intra	MSC	O60682	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	32296183
Intra	MSC	O60682	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	32296183
Intra	MSC	O60682	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Ichthyosis, Congenital, Autosomal Recessive 3	Autosomal Recessive Congenital Ichthyosis 3 ARCI3 Lamellar Ichthyosis 5 Collodion Baby, Self-Healing Ichthyosis, Lamellar, 5, Formerly Li5, Formerly Li5 Self-Healing Collodion Baby Ichthyosis, Congenital, Autosomal Recessive, Type 3
Rhabdomyosarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-101215	Evobrutinib	Inhibitor	99.60%	Phase 3
HY-12042	Pimasertib	Inhibitor	99.60%	Phase 2
HY-135827A	Roginolisib hemifumarate	Inhibitor	99.80%	Phase 2
HY-100501	M2698	Inhibitor	99.74%	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990461	Anti-LIF Antibody (MSC-1)	Inhibitor	98.51%	Phase 1

Pre-clinical Phase

Bioactive Molecules (43)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1410	GsMTx4	Inhibitor	99.89%	Unkown
HY-P1410A	GsMTx4 TFA	Inhibitor	99.85%	Unkown
HY-P1410B	D-GsMTx4	Inhibitor	99.44%	Unkown
HY-123872	MSC1094308	Inhibitor	99.89%	Unkown
HY-132301	MSC-4381	Inhibitor	98.89%	Unkown
HY-P1410C	D-GsMTx4 TFA	Inhibitor	99.89%	Unkown
HY-101611	MSC2530818	Inhibitor	99.62%	Unkown
HY-148518	MSC-1186	Inhibitor	98.95%	Unkown
HY-108628	SU16f	Inhibitor	99.36%	Unkown
HY-N0898A	(-)-Catechin	Inhibitor	98.83%	Unkown
HY-B1890	(±)-Catechin	Inhibitor	99.51%	Unkown
HY-135827	Roginolisib	Inhibitor	99.66%	Unkown
HY-123851	MSC2504877	Inhibitor	99.25%	Unkown
HY-110218	CW 008	Agonist	98.15%	Unkown
HY-147208	MSC-4106	Inhibitor	99.87%	Unkown
HY-177512	MSC778	Inhibitor	/	Unkown
HY-165607S	MCB-22-174		99.78%	Unkown
HY-101611R	MSC2530818 (Standard)	Inhibitor	99.16%	Unkown
HY-126225	SJA710-6		99.62%	Unkown
HY-160053	Gint4.T aptamer sodium	Chemical	94.50%	Unkown
HY-131032	KI-7	Agonist	99.16%	Unkown
HY-169332	Piezo1 agonist 1-d2		/	Unkown
HY-108438	TCS 2210	Inducer	/	Unkown
HY-110262	MSC 2032964A	Inhibitor	/	Unkown
HY-113568	CAY10581	Inhibitor	/	Unkown
HY-12042A	Pimasertib hydrochloride	Inhibitor	/	Unkown
HY-147511	PPARγ agonist 7	Agonist	/	Unkown
HY-168506	MSC-1254	Inhibitor	/	Unkown
HY-170581	PPARγ/δ modulator 2	Modulator	/	Unkown
HY-170837	STAT5-IN-3	Inhibitor	/	Unkown
HY-B1890S	(±)-Catechin-13C3	Inhibitor	/	Unkown
HY-N0008R	Orcinol glucoside (Standard)		/	Unkown
HY-N8917	(3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane	Activator	/	Unkown
HY-P11346	N-Cadherin mimic peptide	Agonist	/	Unkown
HY-P4125	FITC-LC-TAT (47-57)		/	Unkown
HY-RS08707	MSC Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13119	SLC25A37 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-153332	Tankyrase-IN-5	Inhibitor	/	Unkown
HY-168505	MSC-5046	Inhibitor	/	Unkown
HY-177058	DSP30	Agonist	95.27%	Unkown
HY-N2457	Laxogenin	Inhibitor	/	Unkown
HY-RS17017	Msc Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23460	Msc Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MSC	VGNC	VGNC:43436
Rattus norvegicus	MSC	RGD	RGD:1305496
Bos taurus	MSC	VGNC	VGNC:31691
Macaca mulatta	MSC	VGNC	VGNC:74930
Mus musculus	MSC	MGD	MGI:1333884
Others	MSC	NCBI