Fam89b - family with sequence similarity 89, member B Gene

Also Known as MMTV; Mtvr2; 1110021A21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17826

Summary

Enables transcription corepressor binding activity. Involved in establishment of cell polarity; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and positive regulation of cell migration. Located in cytoplasm and lamellipodium. Is expressed in several structures, including branchial arch; cranial ganglion; heart valve; medulla oblongata basal plate mantle layer; and sensory organ. Orthologous to human FAM89B (family with sequence similarity 89 member B). [provided by Alliance of Genome Resources, Apr 2022]

Fam89b Products (2)

mRNA Protein Name
NM_023166.2 NP_075655.2 leucine repeat adapter protein 25 isoform 2
NM_181452.2 NP_852117.2 leucine repeat adapter protein 25 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12646588 MGI
enables transcription corepressor binding IDA
IDA: Inferred from direct assay
12646588 MGI
Biological Process GO Annotation Evidence References Source
involved in establishment of cell polarity IMP
IMP: Inferred from mutant phenotype
25107909 MGI
involved in negative regulation of SMAD protein signal transduction IDA
IDA: Inferred from direct assay
12646588 MGI
involved in negative regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
12646588 MGI
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
25107909 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12646588 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
25107909 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leucine repeat adapter protein 25

  • C184L ORF2 protein

  • C184M protein

  • MMTV receptor

  • mammary tumor virus receptor 2

  • protein FAM89B

Fam89b Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Fam89b Q9QUI1 SKI Homo sapiens P12755
Confocal
12646588
Cross
Fam89b Q9QUI1 SKI Homo sapiens P12755
Pull Down
12646588
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10650 FAM49B (190-198) mouse Inhibitor 99.76% Unkown
HY-RS04722 FAM83B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04727 FAM89A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04729 FAM98B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04730 FAM9B Human Pre-designed siRNA Set A Pre-designed Set / Unkown