Pax5 - paired box 5 Gene

Also Known as KLP; BSAP; EBB-1; Pax-5

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18507

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including adult behavior; animal organ development; and negative regulation of nitrogen compound metabolic process. Located in nucleus. Is expressed in several structures, including central nervous system; future brain; liver; thymus; and urinary system. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to human PAX5 (paired box 5). [provided by Alliance of Genome Resources, Apr 2022]

Pax5 Products (1)

mRNA	Protein	Name
NM_008782.3	NP_032808.1	paired box protein Pax-5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	14594818	MGI
enables DNA binding	IMP IMP: Inferred from mutant phenotype	16618805	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12244173	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	14594818	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12244173	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11799127	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within adult behavior	IMP IMP: Inferred from mutant phenotype	23349049	MGI
acts upstream of or within cerebral cortex development	IMP IMP: Inferred from mutant phenotype	23349049	MGI
acts upstream of or within embryonic cranial skeleton morphogenesis	IMP IMP: Inferred from mutant phenotype	23349049	MGI
acts upstream of or within lateral ventricle development	IMP IMP: Inferred from mutant phenotype	23349049	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15258579	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16618805	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12244173	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15094381	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14594818	MGI
acts upstream of or within skeletal muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	22147266	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	14594818	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
paired box protein Pax-5	B-cell-specific transcription factor paired box gene 5

Pax5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Pax5	Q02650	Paxip1	Mus musculus	Q6NZQ4	Anti Bait CoIP	21552207
Cross	Pax5	Q02650	DAXX	Homo sapiens	Q9UER7	Pull Down	11799127
Cross	Pax5	Q02650	DAXX	Homo sapiens	Q9UER7	CoIP	11799127
Cross	Pax5	Q02650	DAXX	Homo sapiens	Q9UER7	Y2H	11799127

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10092	PAX5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174558	Human PAX5 mRNA		/	Unkown
HY-RS20318	Pax5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26826	Pax5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pax5	NCBI	NCBI:5079