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Paxip1 - PAX interacting (with transcription-activation domain) protein 1 Gene

Also Known as PTIP; D5Ertd149e

Species: Mus musculus

Gene Type: protein coding

Gene ID: 55982

Summary

This gene encodes a nuclear-localized protein that contains six BRCT1 (C-terminal of breast Cancer susceptibility protein) domains. The encoded protein is involved in the repair of DNA double-strand breaks and is necessary for progression through cell division. The protein also functions in the regulation of transcription by recruiting histone methyltransferases to gene promoters bound by the sequence-specific transcription factor paired box protein 2 (Pax2). [provided by RefSeq, Mar 2013]

Paxip1 Products (1)

mRNA	Protein	Name
NM_018878.4	NP_061366.2	PAX-interacting protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10908331	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within DNA damage response	IDA IDA: Inferred from direct assay	17500065	MGI
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	19124460	MGI
involved in adipose tissue development	IMP IMP: Inferred from mutant phenotype	19583951	MGI
involved in chorion development	IMP IMP: Inferred from mutant phenotype	18710940	MGI
involved in endothelial cell migration	IMP IMP: Inferred from mutant phenotype	18710940	MGI
involved in positive regulation of isotype switching	IMP IMP: Inferred from mutant phenotype	20671152	MGI
involved in positive regulation of isotype switching to IgG isotypes	IMP IMP: Inferred from mutant phenotype	26744420	MGI
involved in positive regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	18353733	MGI
involved in positive regulation of transcription initiation by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19583951	MGI
involved in regulation of cell cycle G2/M phase transition	IMP IMP: Inferred from mutant phenotype	19124460	MGI
involved in vasculogenesis	IMP IMP: Inferred from mutant phenotype	18710940	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of histone methyltransferase complex	IDA IDA: Inferred from direct assay	17500065	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10908331	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
PAX-interacting protein 1	PAX transactivation activation domain-interacting protein

Paxip1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Paxip1	Q6NZQ4	Pagr1a	Mus musculus	Q99L02	TSA	26744420
Intra	Paxip1	Q6NZQ4	Pagr1a	Mus musculus	Q99L02	Anti Tag CoIP	26744420
Intra	Paxip1	Q6NZQ4	Pagr1a	Mus musculus	Q99L02	ITC	26744420
Intra	Paxip1	Q6NZQ4	Pagr1a	Mus musculus	Q99L02	Pull Down	26744420
Intra	Paxip1	Q6NZQ4	Pax2	Mus musculus	P32114	Anti Tag CoIP	10908331
Intra	Paxip1	Q6NZQ4	Pax2	Mus musculus	P32114	IF	10908331
Intra	Paxip1	Q6NZQ4	Pax2	Mus musculus	P32114-2	Pull Down	10908331
Cross	Paxip1	Q6NZQ4	PAGR1	Homo sapiens	Q9BTK6	Anti Tag CoIP	17500065
Cross	Paxip1	Q6NZQ4	PAGR1	Homo sapiens	Q9BTK6	Pull Down	19124460
Intra	Paxip1	Q6NZQ4	Pax5	Mus musculus	Q02650	Anti Bait CoIP	21552207
Intra	Paxip1	Q6NZQ4	Pax5	Mus musculus	Q02650	Anti Tag CoIP	21552207
Cross	Paxip1	Q6NZQ4	TP53BP1	Homo sapiens	Q12888	Pull Down	19124460
Cross	Paxip1	Q6NZQ4	TP53BP1	Homo sapiens	Q12888	Anti Tag CoIP	17500065
Cross	Paxip1	Q6NZQ4	TP53BP1	Homo sapiens	Q12888	Anti Tag CoIP	17925232

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10098	PAXIP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Paxip1	NCBI	NCBI:22976