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Pax2 - paired box 2 Gene

Also Known as Opdc; Pax-2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18504

Summary

Enables C2H2 zinc finger domain binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of apoptotic process involved in development; nervous system development; and urogenital system development. Acts upstream of or within several processes, including animal organ development; cellular response to mechanical stimulus; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of protein-DNA complex. Is expressed in several structures, including central nervous system; embryo ectoderm; genitourinary system; sensory organ; and tibia. Used to study renal coloboma syndrome. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 7 and renal coloboma syndrome. Orthologous to human PAX2 (paired box 2). [provided by Alliance of Genome Resources, Apr 2022]

Pax2 Products (10)

mRNA	Protein	Name
NM_001368743.1	NP_001355672.1	paired box protein Pax-2 isoform 1
NM_001368744.1	NP_001355673.1	paired box protein Pax-2 isoform 2
NM_001368745.1	NP_001355674.1	paired box protein Pax-2 isoform 3
NM_001368746.1	NP_001355675.1	paired box protein Pax-2 isoform 4
NM_001368747.1	NP_001355676.1	paired box protein Pax-2 isoform 5
NM_001368748.1	NP_001355677.1	paired box protein Pax-2 isoform 6
NM_001368749.1	NP_001355678.1	paired box protein Pax-2 isoform 8
NM_001368750.1	NP_001355679.1	paired box protein Pax-2 isoform 9
NM_001368751.1	NP_001355680.1	paired box protein Pax-2 isoform 10
NM_011037.5	NP_035167.4	paired box protein Pax-2 isoform 7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables C2H2 zinc finger domain binding	IPI IPI: Inferred from physical interaction	7720589	MGI
enables DNA binding	IDA IDA: Inferred from direct assay	12756174	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11731455	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11731455	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17785448	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10908331	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	17047028	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in brain morphogenesis	IMP IMP: Inferred from mutant phenotype	8951055	MGI
acts upstream of or within branching involved in ureteric bud morphogenesis	IGI IGI: Inferred from genetic interaction	16672320	MGI
acts upstream of or within branching involved in ureteric bud morphogenesis	IMP IMP: Inferred from mutant phenotype	16672320	MGI
acts upstream of or within camera-type eye development	IMP IMP: Inferred from mutant phenotype	12756174	MGI
acts upstream of or within cell fate determination	IMP IMP: Inferred from mutant phenotype	12756174	MGI
involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	17357786	MGI
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	17164400	MGI
involved in cellular response to retinoic acid	IEP IEP: Inferred from expression pattern	20171952	MGI
involved in central nervous system development	IEP IEP: Inferred from expression pattern	1723950	MGI
involved in cochlea development	IMP IMP: Inferred from mutant phenotype	8951055	MGI
involved in cochlea morphogenesis	IGI IGI: Inferred from genetic interaction	20727173	MGI
acts upstream of or within cochlea morphogenesis	IMP IMP: Inferred from mutant phenotype	16916509	MGI
involved in cochlea morphogenesis	IMP IMP: Inferred from mutant phenotype	8951055	MGI
involved in glial cell differentiation	IMP IMP: Inferred from mutant phenotype	8951055	MGI
acts upstream of or within inner ear morphogenesis	IGI IGI: Inferred from genetic interaction	16916509	MGI
involved in inner ear morphogenesis	IGI IGI: Inferred from genetic interaction	20727173	MGI
acts upstream of or within inner ear morphogenesis	IMP IMP: Inferred from mutant phenotype	15242798	MGI
involved in inner ear morphogenesis	IMP IMP: Inferred from mutant phenotype	8951055	MGI
acts upstream of or within kidney development	IGI IGI: Inferred from genetic interaction	16672320	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	16672320	MGI
acts upstream of or within mesenchymal to epithelial transition	IMP IMP: Inferred from mutant phenotype	8575306	MGI
involved in mesenchymal to epithelial transition involved in metanephros morphogenesis	IEP IEP: Inferred from expression pattern	10322633	MGI
involved in mesodermal cell fate specification	IDA IDA: Inferred from direct assay	17785448	MGI
involved in mesonephric duct development	IEP IEP: Inferred from expression pattern	1723950	MGI
involved in mesonephric duct development	IMP IMP: Inferred from mutant phenotype	14695376	MGI
involved in mesonephric tubule development	IEP IEP: Inferred from expression pattern	1723950	MGI
involved in mesonephric tubule development	IMP IMP: Inferred from mutant phenotype	14695376	MGI
involved in mesonephric tubule formation	IMP IMP: Inferred from mutant phenotype	17300925	MGI
acts upstream of or within mesonephros development	IMP IMP: Inferred from mutant phenotype	8575306	MGI
involved in mesonephros development	IMP IMP: Inferred from mutant phenotype	12435636	MGI
involved in metanephric collecting duct development	IMP IMP: Inferred from mutant phenotype	10980123	MGI
involved in metanephric distal convoluted tubule development	IMP IMP: Inferred from mutant phenotype	17314325	MGI
involved in metanephric epithelium development	IEP IEP: Inferred from expression pattern	7856737	MGI
involved in metanephric mesenchymal cell differentiation	IMP IMP: Inferred from mutant phenotype	16368682	MGI
involved in metanephric mesenchyme development	IDA IDA: Inferred from direct assay	20171952	MGI
involved in metanephric nephron tubule formation	IMP IMP: Inferred from mutant phenotype	17314325	MGI
acts upstream of or within metanephros development	IGI IGI: Inferred from genetic interaction	12435636	MGI
acts upstream of or within metanephros development	IMP IMP: Inferred from mutant phenotype	8575306	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	10980123	MGI
involved in negative regulation of apoptotic process involved in metanephric collecting duct development	IMP IMP: Inferred from mutant phenotype	17314325	MGI
involved in negative regulation of apoptotic process involved in metanephric nephron tubule development	IMP IMP: Inferred from mutant phenotype	17314325	MGI
involved in negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis	IMP IMP: Inferred from mutant phenotype	17314325	MGI
involved in negative regulation of mesenchymal cell apoptotic process involved in metanephros development	IMP IMP: Inferred from mutant phenotype	17314325	MGI
acts upstream of or within negative regulation of programmed cell death	IMP IMP: Inferred from mutant phenotype	16672320	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15905411	MGI
involved in nephric duct formation	IDA IDA: Inferred from direct assay	12435636	MGI
involved in neural tube closure	IMP IMP: Inferred from mutant phenotype	8951055	MGI
involved in optic chiasma development	IMP IMP: Inferred from mutant phenotype	8951055	MGI
involved in optic cup morphogenesis involved in camera-type eye development	IMP IMP: Inferred from mutant phenotype	8951055	MGI
involved in optic nerve development	IMP IMP: Inferred from mutant phenotype	8951055	MGI
involved in optic nerve morphogenesis	IMP IMP: Inferred from mutant phenotype	8951055	MGI
involved in optic nerve structural organization	IMP IMP: Inferred from mutant phenotype	8951055	MGI
involved in pancreas development	IEP IEP: Inferred from expression pattern	1723950	MGI
involved in paramesonephric duct development	IMP IMP: Inferred from mutant phenotype	14695376	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	8413205	MGI
involved in positive regulation of DNA-templated transcription	IGI IGI: Inferred from genetic interaction	16319112	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	12435636	MGI
involved in positive regulation of branching involved in ureteric bud morphogenesis	IMP IMP: Inferred from mutant phenotype	17314325	MGI
involved in positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	IGI IGI: Inferred from genetic interaction	12435636	MGI
involved in positive regulation of metanephric DCT cell differentiation	IMP IMP: Inferred from mutant phenotype	17314325	MGI
involved in positive regulation of metanephric glomerulus development	IMP IMP: Inferred from mutant phenotype	17047028	MGI
involved in positive regulation of optic nerve formation	IMP IMP: Inferred from mutant phenotype	18083586	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12200151	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11731455	MGI
involved in pronephric field specification	IEP IEP: Inferred from expression pattern	12435636	MGI
involved in pronephros development	IMP IMP: Inferred from mutant phenotype	12435636	MGI
involved in regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	12435636	MGI
involved in regulation of metanephric nephron tubule epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	17314325	MGI
involved in regulation of metanephros size	IMP IMP: Inferred from mutant phenotype	17881463	MGI
acts upstream of or within regulation of programmed cell death	IGI IGI: Inferred from genetic interaction	16672320	MGI
involved in retinal pigment epithelium development	IMP IMP: Inferred from mutant phenotype	8951055	MGI
involved in stem cell differentiation	IDA IDA: Inferred from direct assay	20171952	MGI
involved in ureter development	IMP IMP: Inferred from mutant phenotype	17881463	MGI
involved in ureter maturation	IMP IMP: Inferred from mutant phenotype	17881463	MGI
involved in ureter morphogenesis	IEP IEP: Inferred from expression pattern	1723950	MGI
acts upstream of or within ureter morphogenesis	IGI IGI: Inferred from genetic interaction	21731775	MGI
acts upstream of or within ureteric bud development	IGI IGI: Inferred from genetic interaction	16018995	MGI
involved in urogenital system development	IGI IGI: Inferred from genetic interaction	12435636	MGI
acts upstream of or within urogenital system development	IMP IMP: Inferred from mutant phenotype	8575306	MGI
involved in vestibulocochlear nerve formation	IMP IMP: Inferred from mutant phenotype	8951055	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	10536059	MGI
part of protein-DNA complex	IDA IDA: Inferred from direct assay	17785448	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	17785448	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
paired box protein Pax-2	optic disc coloboma paired box gene 2

Pax2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Pax2	P32114	Paxip1	Mus musculus	Q6NZQ4	Anti Tag CoIP	10908331

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124838	EG1		98.26%	Unkown
HY-RS10089	PAX2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174561	Human PAX2 mRNA		/	Unkown
HY-RS22268	Pax2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28791	Pax2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pax2	NCBI	NCBI:5076