Furin - furin (paired basic amino acid cleaving enzyme) Gene

Also Known as Fur; PACE; SPC1; Pcsk3; 9130404I01Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18550

Summary

This gene encodes a calcium-dependent serine endoprotease that proteolytically activates different proprotein substrates traversing the secretory pathway. The encoded protein undergoes proteolytic autoactivation during which an N-terminal propeptide is cleaved to generate the mature protein. Mice lacking the encoded protein die at an embryonic stage and display hemodynamic insufficiency, cardiac ventral closure defect, axial rotation defect and abnormal yolk sac vasculature. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

Furin Products (2)

mRNA Protein Name
NM_001081454.2 NP_001074923.1 furin preproprotein
NM_011046.3 NP_035176.1 furin preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9412467 MGI
enables serine-type endopeptidase activity EXP
EXP: Inferred from Experiment
12447384 MGI
Biological Process GO Annotation Evidence References Source
involved in blastocyst formation IGI
IGI: Inferred from genetic interaction
26416966 MGI
acts upstream of or within protein processing IDA
IDA: Inferred from direct assay
20530870 MGI
acts upstream of or within protein processing IMP
IMP: Inferred from mutant phenotype
21147780 MGI
acts upstream of or within regulation of cholesterol transport IMP
IMP: Inferred from mutant phenotype
21147780 MGI
acts upstream of or within regulation of signal transduction IDA
IDA: Inferred from direct assay
17936261 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

furin

  • dibasic-processing enzyme

  • paired basic amino acid residue cleaving enzyme

  • prohormone convertase 3

  • proprotein convertase subtilisin/kexin type 3

  • subtilisin pro-protein processing enzyme

Recombinant Furin Proteins

Cat. No. Product Name Accession Purity
HY-P79228 Furin/PCSK3 Protein, Mouse (HEK293, His) P23188 (Q25-E714) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-147140 BOS-318 99.24% Unkown
HY-P4548 Boc-Arg-Val-Arg-Arg-AMC hydrochloride 99.55% Unkown
HY-P5062A DEC-RVRK-CMK TFA Inhibitor 99.04% Unkown
HY-110147B SSM3 tetraTFA hydrate 99.9% Unkown
HY-P5062 DEC-RVRK-CMK Inhibitor / Unkown
HY-183626 PAI-1-IN-1 Activator 99.45% Unkown
HY-P11413 PAI-1 Inhibitor / Unkown
HY-P3797 Furin Substrate / Unkown
HY-180145 Furin-IN-3 Inhibitor / Unkown
HY-110147A SSM3 tetraTFA / Unkown
HY-163738 Furin-IN-2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Furin NCBI NCBI:5045