Prkci - protein kinase C, iota Gene

Also Known as Pkci; Pkcl; Prkcl; PKClambda; mKIAA4165; aPKClambda; 2310021H13Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18759

About Prkci

Chromosome 3: 31,049,896-31,107,108 forward strand.GRCm39:CM000996.3

This gene has 5 transcripts (splice variants), 228 orthologues, 9 paralogues and is associated with 18 phenotypes. Ubiquitous expression in bladder adult (RPKM 26.7), placenta adult (RPKM 19.4) and 28 other tissues.

Summary

Enables protein kinase C activity. Involved in several processes, including cellular response to Insulin stimulus; positive regulation of glucose import; and positive regulation of protein localization to plasma membrane. Acts upstream of or within actin filament organization; establishment of apical/basal cell polarity; and eye photoreceptor cell development. Located in several cellular components, including Schmidt-Lanterman incisure; apical plasma membrane; and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; lung; and sensory organ. Used to study abdominal obesity-metabolic syndrome; obesity; and type 2 diabetes mellitus. Orthologous to human PRKCI (protein kinase C iota). [provided by Alliance of Genome Resources, Apr 2022]

Prkci Products (1)

mRNA	Protein	Name
NM_008857.3	NP_032883.2	protein kinase C iota type

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity	IDA IDA: Inferred from direct assay	9819385	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16792529	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within actin filament organization	IMP IMP: Inferred from mutant phenotype	15322187	MGI
involved in cellular response to insulin stimulus	IMP IMP: Inferred from mutant phenotype	9819385	MGI
acts upstream of or within establishment of apical/basal cell polarity	IMP IMP: Inferred from mutant phenotype	16267237	MGI
acts upstream of or within eye photoreceptor cell development	IMP IMP: Inferred from mutant phenotype	16267237	MGI
involved in positive regulation of D-glucose import	IMP IMP: Inferred from mutant phenotype	9819385	MGI
involved in positive regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	9819385	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in Schmidt-Lanterman incisure	IDA IDA: Inferred from direct assay	20237282	MGI
located in apical part of cell	IDA IDA: Inferred from direct assay	14758363	MGI
located in apical plasma membrane	IDA IDA: Inferred from direct assay	16892058	MGI
located in brush border	IDA IDA: Inferred from direct assay	33129760	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	10882525	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10882525	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prkci Protein Structure

PB1_aPKC

C1_aPKC

STKc_aPKC_iota

0
100
200
300
400
500
595 a.a.

Protein Preferred Names	Protein Names
protein kinase C iota type	aPKC-lambda/iota atypical protein kinase C-lambda/iota nPKC-iota protein kinase C, lambda

Prkci Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Prkci	Q62074	PARD3	Homo sapiens	Q8TEW0	X-Ray Diffraction	22579248

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS11134	PRKCI Human Pre-designed siRNA Set A		/	Unkown
HY-RS11135	Prkci Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS11136	Prkci Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28112	Hint1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prkci	NCBI	NCBI:5584