Prlr - prolactin receptor Gene

Also Known as Pr-1; Pr-3; Prlr-rs1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19116

Summary

Enables Prolactin receptor activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including gland development; receptor signaling pathway via JAK-STAT; and response to bacterium. Predicted to be located in cell surface. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and limb segment. Used to study familial medullary thyroid carcinoma. Human ortholog(s) of this gene implicated in hyperprolactinemia. Orthologous to human PRLR (Prolactin receptor). [provided by Alliance of Genome Resources, Apr 2022]

Prlr Products (6)

mRNA Protein Name
NM_001253781.1 NP_001240710.1 prolactin receptor isoform 2 precursor
NM_001253782.2 NP_001240711.1 prolactin receptor isoform 3 precursor
NM_011169.5 NP_035299.4 prolactin receptor isoform 1 precursor
NM_001253781.1 NP_001240710.1 prolactin receptor isoform 2 precursor
NM_001253782.2 NP_001240711.1 prolactin receptor isoform 3 precursor
NM_011169.5 NP_035299.4 prolactin receptor isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables prolactin receptor activity IDA
IDA: Inferred from direct assay
6303755 MGI
enables prolactin receptor activity IMP
IMP: Inferred from mutant phenotype
11706048 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
20075866 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell surface receptor signaling pathway via JAK-STAT IMP
IMP: Inferred from mutant phenotype
16469767 MGI
acts upstream of or within lactation IGI
IGI: Inferred from genetic interaction
11445538 MGI
acts upstream of or within lactation IMP
IMP: Inferred from mutant phenotype
11706048 MGI
acts upstream of or within mammary gland alveolus development IGI
IGI: Inferred from genetic interaction
11445538 MGI
acts upstream of or within mammary gland alveolus development IMP
IMP: Inferred from mutant phenotype
16469767 MGI
acts upstream of or within mammary gland epithelial cell differentiation IGI
IGI: Inferred from genetic interaction
16469767 MGI
acts upstream of or within mammary gland epithelium development IMP
IMP: Inferred from mutant phenotype
12040017 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
18253483 MGI
acts upstream of or within prostate gland growth IMP
IMP: Inferred from mutant phenotype
12810576 MGI
acts upstream of or within regulation of cell adhesion IMP
IMP: Inferred from mutant phenotype
11706048 MGI
acts upstream of or within regulation of epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
11706048 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prolactin receptor

  • PRL-R

  • prolactin receptor related sequence 1

Recombinant Prlr Proteins

Cat. No. Product Name Accession Purity
HY-P71235 Prolactin Receptor Protein, Mouse (HEK293, His) Q08501 (Q20-D229) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73694 Prolactin Receptor Protein, Mouse (HEK293, His-Fc) Q08501 (Q20-D229) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P991358 XOMA-213 Inhibitor 98.46% Phase 1
HY-P99881 Rolinsatamab talirine / Phase 1

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11163 PRLR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11411 PTP4A3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17413 Prlr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23867 Prlr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99238 Rolinsatamab 96.98% Unkown
HY-P992449 REGN2878 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prlr NCBI NCBI:5618