Ptk2b - PTK2 protein tyrosine kinase 2 beta Gene

Also Known as CAKB; FAK2; PYK2; CADTK; FADK2; Raftk; CAKbeta; E430023O05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19229

Summary

Enables non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including regulation of cell migration; regulation of intracellular signal transduction; and regulation of phosphate metabolic process. Acts upstream of or within cellular response to fluid shear stress and protein phosphorylation. Located in nucleus and perinuclear region of cytoplasm. Is expressed in several structures, including blastocyst; early embryo; gonad; gonad primordium; and heart. Human ortholog(s) of this gene implicated in breast Cancer and hypertension. Orthologous to human PTK2B (protein tyrosine kinase 2 beta). [provided by Alliance of Genome Resources, Apr 2022]

Ptk2b Products (4)

mRNA Protein Name
NM_001162365.1 NP_001155837.1 protein-tyrosine kinase 2-beta isoform 2
NM_001162366.2 NP_001155838.1 protein-tyrosine kinase 2-beta isoform 1
NM_001360233.1 NP_001347162.1 protein-tyrosine kinase 2-beta isoform 1
NM_172498.3 NP_766086.2 protein-tyrosine kinase 2-beta isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables non-membrane spanning protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
17537919 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11238453 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
11274221 MGI
Biological Process GO Annotation Evidence References Source
involved in bone resorption IMP
IMP: Inferred from mutant phenotype
14739300 MGI
acts upstream of or within cellular response to fluid shear stress IMP
IMP: Inferred from mutant phenotype
24841674 MGI
involved in chemokine-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
12960403 MGI
involved in cortical cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
12960403 MGI
involved in marginal zone B cell differentiation IMP
IMP: Inferred from mutant phenotype
10881171 MGI
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
19880522 MGI
involved in negative regulation of bone mineralization IMP
IMP: Inferred from mutant phenotype
17537919 MGI
involved in peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
17537919 MGI
involved in positive regulation of B cell chemotaxis IMP
IMP: Inferred from mutant phenotype
10881171 MGI
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
17698736 MGI
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
19880522 MGI
involved in positive regulation of endothelial cell migration IMP
IMP: Inferred from mutant phenotype
17698736 MGI
acts upstream of positive effect positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
12960403 MGI
involved in positive regulation of ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
19880522 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
11274221 MGI
involved in regulation of actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
12960403 MGI
involved in regulation of macrophage chemotaxis IMP
IMP: Inferred from mutant phenotype
12960403 MGI
involved in regulation of postsynaptic density assembly IDA
IDA: Inferred from direct assay
28555636 MGI
involved in regulation of postsynaptic density assembly IMP
IMP: Inferred from mutant phenotype
28555636 MGI
involved in regulation of release of sequestered calcium ion into cytosol IMP
IMP: Inferred from mutant phenotype
12960403 MGI
involved in sprouting angiogenesis IMP
IMP: Inferred from mutant phenotype
21640103 MGI
involved in vascular endothelial growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17698736 MGI
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
28555636 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
28555636 MGI
located in nucleus IDA
IDA: Inferred from direct assay
19880522 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
24841674 MGI
is active in postsynaptic density, intracellular component IDA
IDA: Inferred from direct assay
28555636 MGI
is active in presynapse IDA
IDA: Inferred from direct assay
28555636 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein-tyrosine kinase 2-beta

  • CAK-beta

  • calcium-dependent tyrosine kinase

  • calcium-regulated non-receptor proline-rich tyrosine kinase

  • cell adhesion kinase beta

  • cellular adhesion kinase beta

  • focal adhesion kinase 2

  • proline-rich tyrosine kinase 2

  • related adhesion focal tyrosine ki

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148061 DB1113 99.86% Unkown
HY-148063 DB0614 96.07% Unkown
HY-148066 DB0662 Degrader 99.66% Unkown
HY-RS26981 Ptk2b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11402 PTK2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20473 Ptk2b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptk2b NCBI NCBI:2185