GRAMD2A - GRAM domain containing 2A Gene

Also Known as GRAMD2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 196996

Summary

Enables phosphatidylinositol binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in endoplasmic reticulum-plasma membrane tethering and regulation of store-operated calcium entry. Located in endoplasmic reticulum membrane; organelle membrane contact site; and plasma membrane. [provided by Alliance of Genome Resources, Jun 2026]
Biased expression in placenta (RPKM 18.3), lung (RPKM 8.8) and 4 other tissues.

GRAMD2A Products (1)

mRNA Protein Name
NM_001012642.3 NP_001012660.1 GRAM domain-containing protein 2A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphatidylinositol binding IDA
IDA: Inferred from direct assay
29469807 GOA
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: Inferred from direct assay
29469807 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in endoplasmic reticulum-plasma membrane tethering IDA
IDA: Inferred from direct assay
29469807 GOA
involved in regulation of store-operated calcium entry IDA
IDA: Inferred from direct assay
29469807 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
29469807 GOA
located in organelle membrane contact site IDA
IDA: Inferred from direct assay
29469807 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
29469807 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRAMD2A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GRAMD2A Q8IUY3 TRAF3IP3 Homo sapiens Q9Y228
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05772 GRAMD1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown