GKN2 - gastrokine 2 Gene

Also Known as GDDR; TFIZ1; PRO813; BRICD1B; VLTI465

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 200504

About GKN2

Cytogenetic location: 2p13.3 Genomic coordinates (GRCh38): 2:68,945,232-68,952,893 (from NCBI)

This gene has 2 transcripts (splice variants), 126 orthologues and 2 paralogues. Restricted expression toward stomach (RPKM 1463.9).

Summary

The secretory protein encoded by this gene is produced in gastric surface mucous cells, where it can bind trefoil factor family peptide 1 or gastrokine-1. This gene may be a tumor suppressor gene, as its expression is markedly decreased in gastric Cancer tissues. The encoded protein interacts with gastrokine-1 and regulates homeostasis of the gastric mucosa. [provided by RefSeq, Dec 2015]

GKN2 Products (1)

mRNA Protein Name
NM_182536.3 NP_872342.2 gastrokine-2 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GKN2 Protein Structure

BRICHOS

BRICHOS: BRICHOS domain (55 - 150)

  • 0
  • 100
  • 184 a.a.
Protein Preferred Names Protein Names

gastrokine-2

  • BRICHOS domain containing 1B

GKN2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GKN2 Q86XP6 TMEM237 Homo sapiens Q96Q45-2
Validated Y2H
32296183
Intra
GKN2 Q86XP6 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
Intra
GKN2 Q86XP6 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
Intra
GKN2 Q86XP6 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
GKN2 Q86XP6 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05462 GKN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris GKN2 VGNC VGNC:41247
Bos taurus GKN2 VGNC VGNC:29389
Mus musculus GKN2 MGD MGI:1913534
Macaca mulatta GKN2 VGNC VGNC:72995
Rattus norvegicus GKN2 RGD RGD:1311934
Felis catus GKN2 VGNC VGNC:62571
Others GKN2 NCBI