Ryr2 - ryanodine receptor 2, cardiac Gene

Also Known as RYR-2; 9330127I20Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20191

Summary

Enables several functions, including Calmodulin binding activity; identical protein binding activity; and ryanodine-sensitive calcium-release channel activity. Involved in several processes, including cellular response to organonitrogen compound; regulation of heart contraction; and release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. Acts upstream of or within several processes, including calcium ion transport; left ventricular cardiac muscle tissue morphogenesis; and response to caffeine. Located in Z disc; sarcoplasmic reticulum membrane; and smooth endoplasmic reticulum. Part of Calcium Channel complex. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and respiratory system. Used to study arrhythmogenic right ventricular dysplasia 2; catecholaminergic polymorphic ventricular tachycardia 1; and heart disease. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy; arrhythmogenic right ventricular dysplasia 2; and catecholaminergic polymorphic ventricular tachycardia 1. Orthologous to human RYR2 (ryanodine receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Ryr2 Products (1)

mRNA Protein Name
NM_023868.2 NP_076357.2 ryanodine receptor 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium channel activity IDA
IDA: Inferred from direct assay
9628868 MGI
enables calmodulin binding IDA
IDA: Inferred from direct assay
17431507 MGI
enables enzyme binding IPI
IPI: Inferred from physical interaction
16213210 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
12324472 MGI
enables intracellularly gated calcium channel activity IDA
IDA: Inferred from direct assay
10473538 MGI
enables organic cyclic compound binding IPI
IPI: Inferred from physical interaction
17431507 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16352659 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
12676814 MGI
enables ryanodine-sensitive calcium-release channel activity IDA
IDA: Inferred from direct assay
14593104 MGI
Biological Process GO Annotation Evidence References Source
involved in Purkinje myocyte to ventricular cardiac muscle cell signaling IMP
IMP: Inferred from mutant phenotype
17872467 MGI
acts upstream of or within calcium ion transmembrane import into cytosol IMP
IMP: Inferred from mutant phenotype
17431507 MGI
acts upstream of or within calcium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
21673970 MGI
acts upstream of or within calcium ion transport IDA
IDA: Inferred from direct assay
14593104 MGI
involved in calcium ion transport IDA
IDA: Inferred from direct assay
10473538 MGI
involved in calcium ion transport IMP
IMP: Inferred from mutant phenotype
9628868 MGI
acts upstream of or within calcium ion transport IPI
IPI: Inferred from physical interaction
16204356 MGI
involved in calcium-mediated signaling IMP
IMP: Inferred from mutant phenotype
9628868 MGI
acts upstream of or within cardiac muscle hypertrophy IMP
IMP: Inferred from mutant phenotype
17431507 MGI
acts upstream of or within cellular response to caffeine IDA
IDA: Inferred from direct assay
12089338 MGI
involved in cellular response to caffeine IDA
IDA: Inferred from direct assay
9628868 MGI
involved in cellular response to epinephrine stimulus IMP
IMP: Inferred from mutant phenotype
17872467 MGI
involved in embryonic heart tube morphogenesis IMP
IMP: Inferred from mutant phenotype
9628868 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
12089338 MGI
involved in intracellular calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
9628868 MGI
acts upstream of or within left ventricular cardiac muscle tissue morphogenesis IMP
IMP: Inferred from mutant phenotype
17431507 MGI
acts upstream of or within positive regulation of heart rate IMP
IMP: Inferred from mutant phenotype
12089338 MGI
involved in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IGI
IGI: Inferred from genetic interaction
12837242 MGI
involved in regulation of heart rate IMP
IMP: Inferred from mutant phenotype
17872467 MGI
involved in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IDA
IDA: Inferred from direct assay
20226167 MGI
acts upstream of or within release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IMP
IMP: Inferred from mutant phenotype
12089338 MGI
acts upstream of or within response to caffeine IDA
IDA: Inferred from direct assay
14593104 MGI
involved in response to caffeine IDA
IDA: Inferred from direct assay
10473538 MGI
involved in response to hypoxia IDA
IDA: Inferred from direct assay
19120137 MGI
involved in type B pancreatic cell apoptotic process IMP
IMP: Inferred from mutant phenotype
15044459 MGI
involved in ventricular cardiac muscle cell action potential IMP
IMP: Inferred from mutant phenotype
17872467 MGI
Cellular Component GO Annotation Evidence References Source
located in Z disc IDA
IDA: Inferred from direct assay
16204356 MGI
part of calcium channel complex IDA
IDA: Inferred from direct assay
16213210 MGI
located in membrane IDA
IDA: Inferred from direct assay
17431507 MGI
located in sarcomere IDA
IDA: Inferred from direct assay
20226167 MGI
located in sarcoplasmic reticulum IDA
IDA: Inferred from direct assay
12919952 MGI
located in sarcoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
14592808 MGI
located in smooth endoplasmic reticulum IDA
IDA: Inferred from direct assay
23454728 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ryanodine receptor 2

  • calcium release channel

  • cardiac muscle ryanodine receptor

  • cardiac muscle ryanodine receptor-calcium release channel

  • ryanodine receptor type 2

  • type 2 ryanodine receptor

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-W010950 Flecainide Inhibitor 99.98% Unkown
HY-W010950A Flecainide hydrochloride Inhibitor 99.93% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-119850 Aladorian Modulator 99.55% Phase 2

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-149662 TMDJ-035 Inhibitor 99.92% Unkown
HY-15292 S107 Ligand 99.77% Unkown
HY-N7491A Ent-(+)-Verticilide Inhibitor 99.91% Unkown
HY-P5114A Maurocalcine TFA Agonist 95.09% Unkown
HY-RS12369 RYR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-103059 SOICR-IN-1 99.62% Unkown
HY-P5114 Maurocalcine Agonist / Unkown
HY-Z7733 O-Desmethylcarvedilol Inhibitor 97.4% Unkown
HY-119850A Aladorian sodium Modulator / Unkown
HY-178344 Multi-target kinase-IN-6 Activator / Unkown
HY-P5319 MCaE12A Activator / Unkown
HY-149779 RyR2 stabilizer-1 Modulator / Unkown
HY-164631 EL20 Inhibitor / Unkown
HY-166478S O-Desmethyl carvedilol-d5 Inhibitor / Unkown
HY-RS19951 Ryr2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26453 Ryr2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W010950S Flecainide-d3 99.9% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ryr2 NCBI NCBI:6262