Sag - S-antigen, retina and pineal gland (arrestin) Gene

Also Known as Arr1; Irbp; arrestin; A930001K18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20215

Summary

Enables opsin binding activity and phosphoprotein binding activity. Predicted to be involved in G protein-coupled receptor internalization. Located in photoreceptor inner segment and photoreceptor outer segment. Is expressed in eye and retina outer nuclear layer. Human ortholog(s) of this gene implicated in Oguchi disease-1; hereditary night blindness; and retinitis pigmentosa 47. Orthologous to human SAG (S-antigen visual Arrestin). [provided by Alliance of Genome Resources, Apr 2022]

Sag Products (1)

mRNA Protein Name
NM_009118.2 NP_033144.1 S-arrestin

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables opsin binding IDA
IDA: Inferred from direct assay
12486395 MGI
enables phosphoprotein binding IDA
IDA: Inferred from direct assay
12486395 MGI
Cellular Component GO Annotation Evidence References Source
located in photoreceptor inner segment IDA
IDA: Inferred from direct assay
22869374 MGI
located in photoreceptor outer segment IDA
IDA: Inferred from direct assay
22869374 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

S-arrestin

  • 48 kDa protein

  • S-AG

  • arrestin 1

  • retinal S-antigen

  • rod arrestin

  • rod photoreceptor arrestin

  • visual arrestin 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-18542 KT195 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (22)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12848 SAG Agonist 99.79% Unkown
HY-12848B SAG hydrochloride Agonist 99.91% Unkown
HY-12848C SAG dihydrochloride Agonist 98.23% Unkown
HY-117771 DO34 Inhibitor 99.30% Unkown
HY-B0633C Hyaluronic acid (Mw:1000-2000Da) / Unkown
HY-124899 Hh-Ag1.5 Agonist 99.90% Unkown
HY-163455 pan-HCN-IN-1 Inhibitor 99.84% Unkown
HY-157993 SAG-524 Inhibitor 98.50% Unkown
HY-12848R SAG (Standard) Agonist 99.56% Unkown
HY-110240 IHR-1 Antagonist 98.05% Unkown
HY-117771A DO34 analog Inhibitor 98.42% Unkown
HY-RS12096 RNF7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-12848A (Rac)-SAG Agonist / Unkown
HY-12848S SAG-d3 Inhibitor 99.85% Unkown
HY-182641 SAG analog (cis-isomer) Activator / Unkown
HY-D3314 1-NBD-Stearoyl-2-arachidonoyl-sn-glycerol Substrate / Unkown
HY-N15152 Isoaesculioside D / Unkown
HY-RS03820 DMBT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12415 SAG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-12848G SAG (GMP) Agonist / Unkown
HY-RS16512 Sag Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22944 Sag Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sag NCBI NCBI:6295