Sstr2 - somatostatin receptor 2 Gene

Also Known as SS2R; sst2; SRIF-1; SSTR-2; Smstr2; Smstr-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20606

About Sstr2

Chromosome 11: 113,510,168-113,516,854 forward strand.GRCm39:CM001004.3

This gene has 3 transcripts (splice variants), 264 orthologues, 15 paralogues and is associated with 32 phenotypes. Biased expression in whole brain E14.5 (RPKM 13.8), CNS E14 (RPKM 13.2) and 13 other tissues.

Summary

The protein encoded by this gene is a receptor for somatostatin, which acts at many sites to inhibit the release of several Hormones and Other secretory proteins. The encoded protein is a member of the superfamily of receptors having seven transmembrane segments and is involved in many processes, including adenylyl cyclase inhibition, phosphotyrosine Phosphatase stimulation, and inhibition of calcium entry and cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Sstr2 Products (2)

mRNA Protein Name
NM_009217.5 NP_033243.2 somatostatin receptor type 2 isoform B
NM_001042606.3 NP_001036071.1 somatostatin receptor type 2 isoform A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables somatostatin receptor activity IDA
IDA: Inferred from direct assay
1346068 MGI
enables somatostatin receptor activity IMP
IMP: Inferred from mutant phenotype
7929134 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
7929134 MGI
acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
9166719 MGI
acts upstream of or within neuropeptide signaling pathway IDA
IDA: Inferred from direct assay
9166719 MGI
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
7929134 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
9166719 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sstr2 Protein Structure

7tmA_SSTR2

7tmA_SSTR2: cd15971 (43 - 322)

7tmA_SSTR2

7tmA_SSTR2: cd15971 (44 - 70)

7tmA_SSTR2

7tmA_SSTR2: cd15971 (77 - 103)

7tmA_SSTR2

7tmA_SSTR2: cd15971 (114 - 144)

7tmA_SSTR2

7tmA_SSTR2: cd15971 (156 - 178)

7tmA_SSTR2

7tmA_SSTR2: cd15971 (204 - 233)

7tmA_SSTR2

7tmA_SSTR2: cd15971 (248 - 278)

7tmA_SSTR2

7tmA_SSTR2: cd15971 (290 - 315)

  • 0
  • 100
  • 200
  • 300
  • 369 a.a.
Protein Preferred Names Protein Names

somatostatin receptor type 2

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P0036 Octreotide Agonist 99.96% Unkown
HY-P0036B Octreotide pamoate Agonist / Unkown

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-P5362 NODAGA-LM3 Antagonist 99.65% Phase 2
HY-P0024 Veldoreotide Activator / Phase 2
HY-106103 Seglitide Modulator 99.30% Phase 2
HY-P3294 Onzigolide Agonist / Phase 2

Pre-clinical Phase

Bioactive Molecules (21)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1932 Cortistatin-14 99.98% Unkown
HY-P1202 CYN 154806 Antagonist 99.90% Unkown
HY-P10137 Satoreotide Antagonist 98.80% Unkown
HY-P3124A BIM-23190 hydrochloride Agonist 99.33% Unkown
HY-P1202A CYN 154806 TFA Antagonist 98.30% Unkown
HY-P0024A Veldoreotide TFA Agonist 98.97% Unkown
HY-P4452 PRL 2915 Antagonist 99.92% Unkown
HY-P2090A Angiopeptin TFA Agonist 99.01% Unkown
HY-P3618 Cortistatin-29 (reduced) 98.12% Unkown
HY-P5362A NODAGA-LM3 TFA Antagonist / Unkown
HY-P4469 PRL 3195 Antagonist / Unkown
HY-P10239 Tyr3-Octreotate Ligand 99.76% Unkown
HY-P2545 [Tyr1]-Somatostatin-14 / Unkown
HY-P2150 Cortistatin-29 (rat) / Unkown
HY-P0042 BIM-23197 Agonist / Unkown
HY-P11485 JR11-PEG3-HBED-CC-PSMA-03 Antagonist / Unkown
HY-110161 sst2 Receptor agonist-1 Agonist / Unkown
HY-P3124 BIM-23190 Agonist / Unkown
HY-P2090 Angiopeptin Agonist / Unkown
HY-P11488 JR11-PEG3-DOTA-PSMA-03 Ligand / Unkown
HY-P2434 AP102 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sstr2 NCBI NCBI:6752