Sphk1 - sphingosine kinase 1 Gene

Also Known as Sk1; Spk1; 1110006G24Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20698

About Sphk1

Chromosome 11: 116,421,751-116,427,501 forward strand.GRCm39:CM001004.3

This gene has 17 transcripts (splice variants), 277 orthologues, 4 paralogues and is associated with 21 phenotypes. Broad expression in lung adult (RPKM 8.3), duodenum adult (RPKM 6.9) and 25 other tissues.

Summary

This gene encodes a kinase that phosphorylates sphingosine into sphingosine-1-phosphate, which is involved in cell differentiation, motility, and Apoptosis. The encoded protein plays a role in maintaining cellular levels of sphingosine-1-phosphate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Sphk1 Products (10)

mRNA Protein Name
NM_001172475.1 NP_001165946.1 sphingosine kinase 1 isoform 3
NM_001372488.1 NP_001359417.1 sphingosine kinase 1 isoform 3
NM_001372485.1 NP_001359414.1 sphingosine kinase 1 isoform 4
NM_025367.7 NP_079643.2 sphingosine kinase 1 isoform 2
NM_001372489.1 NP_001359418.1 sphingosine kinase 1 isoform 3
NM_001172472.2 NP_001165943.1 sphingosine kinase 1 isoform 2
NM_001372487.1 NP_001359416.1 sphingosine kinase 1 isoform 4
NM_001372486.1 NP_001359415.1 sphingosine kinase 1 isoform 2
NM_001372484.1 NP_001359413.1 sphingosine kinase 1 isoform 2
NM_001172473.1 NP_001165944.1 sphingosine kinase 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables D-erythro-sphingosine kinase activity IDA
IDA: Inferred from direct assay
9726979 MGI
enables acetyltransferase activity IMP
IMP: Inferred from mutant phenotype
29662056 MGI
enables sphingosine kinase activity IDA
IDA: Inferred from direct assay
25417698 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA biosynthetic process IMP
IMP: Inferred from mutant phenotype
23651497 MGI
acts upstream of or within blood vessel development IGI
IGI: Inferred from genetic interaction
16314531 MGI
acts upstream of or within brain development IGI
IGI: Inferred from genetic interaction
16314531 MGI
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
16314531 MGI
acts upstream of or within cellular response to hydrogen peroxide IDA
IDA: Inferred from direct assay
23651497 MGI
involved in cellular response to vascular endothelial growth factor stimulus IDA
IDA: Inferred from direct assay
25417698 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
18305483 MGI
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
16118219 MGI
involved in negative regulation of ceramide biosynthetic process IMP
IMP: Inferred from mutant phenotype
16118219 MGI
involved in phosphorylation IDA
IDA: Inferred from direct assay
9726979 MGI
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
16314531 MGI
acts upstream of or within positive regulation of mitotic nuclear division IGI
IGI: Inferred from genetic interaction
23651497 MGI
involved in protein acetylation IMP
IMP: Inferred from mutant phenotype
29662056 MGI
involved in regulation of endocytosis IMP
IMP: Inferred from mutant phenotype
27806293 MGI
involved in regulation of endosomal vesicle fusion IMP
IMP: Inferred from mutant phenotype
27806293 MGI
acts upstream of or within regulation of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
18305483 MGI
involved in regulation of microglial cell activation IMP
IMP: Inferred from mutant phenotype
29662056 MGI
involved in regulation of neuroinflammatory response IMP
IMP: Inferred from mutant phenotype
29662056 MGI
involved in regulation of phagocytosis IMP
IMP: Inferred from mutant phenotype
29662056 MGI
acts upstream of or within sphingolipid mediated signaling pathway IDA
IDA: Inferred from direct assay
23651497 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16118219 MGI
located in cytoplasm IMP
IMP: Inferred from mutant phenotype
27806293 MGI
located in endocytic vesicle IDA
IDA: Inferred from direct assay
27806293 MGI
located in nucleus IDA
IDA: Inferred from direct assay
29662056 MGI
located in presynapse IDA
IDA: Inferred from direct assay
24929359 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sphk1 Protein Structure

PLN02958

PLN02958: cl29912 (10 - 343)

  • 0
  • 100
  • 200
  • 300
  • 382 a.a.
Protein Preferred Names Protein Names

sphingosine kinase 1

  • acetyltransferase SPHK1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (25)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15425 PF-543 Inhibitor 99.85% Unkown
HY-15425A PF-543 Citrate Inhibitor 99.47% Unkown
HY-124042 K6PC-5 Activator 99.27% Unkown
HY-119016 SK1-I Inhibitor 98.83% Unkown
HY-19794 MP-A08 Inhibitor 98.0% Unkown
HY-12892 SKI-178 Inhibitor 99.29% Unkown
HY-101572 MHP Activator 98.57% Unkown
HY-101805 SK1-IN-1 Inhibitor 98.10% Unkown
HY-147282 Amgen-23 Inhibitor 98.11% Unkown
HY-148707 SphK1&2-IN-1 Inhibitor 98.47% Unkown
HY-120268A SLM6031434 hydrochloride Inhibitor 99.1% Unkown
HY-117563 CAY10621 Inhibitor 99.3% Unkown
HY-120152A SLP7111228 hydrochloride Inhibitor 98.01% Unkown
HY-15425B PF-543 hydrochloride Inhibitor / Unkown
HY-112385 ABC294735 Inhibitor / Unkown
HY-150615 SphK1-IN-2 Inhibitor / Unkown
HY-143296 SphK1-IN-1 Inhibitor / Unkown
HY-178992 SphK1-IN-4 Inhibitor / Unkown
HY-120268 SLM6031434 Inhibitor / Unkown
HY-12896 SLR080811 Inhibitor / Unkown
HY-120152 SLP7111228 Inhibitor / Unkown
HY-184271 SphK1-IN-5 Inhibitor / Unkown
HY-124368 RB-042 Inhibitor / Unkown
HY-148262 SphK1-IN-3 Inhibitor / Unkown
HY-12900 RB-005 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sphk1 NCBI NCBI:8877