Spp1 - secreted phosphoprotein 1 Gene

Also Known as OP; 2AR; Bsp; Eta; Opn; Ric; BNSP; BSPI; Opnl; Apl-1; ETA-1; Spp-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20750

Summary

Enables extracellular matrix binding activity. Acts upstream of or within several processes, including cellular ion homeostasis; cellular response to leukemia inhibitory factor; and neutrophil chemotaxis. Located in apical part of cell and cytoplasm. Is expressed in several structures, including alimentary system; brain; metanephros; reproductive system; and skeleton. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); and hepatitis. Orthologous to human SPP1 (secreted phosphoprotein 1). [provided by Alliance of Genome Resources, Apr 2022]

Spp1 Products (5)

mRNA Protein Name
NM_001204201.1 NP_001191130.1 osteopontin isoform 1
NM_001204202.1 NP_001191131.1 osteopontin isoform 2
NM_001204203.1 NP_001191132.1 osteopontin isoform 3 precursor
NM_001204233.1 NP_001191162.1 osteopontin isoform 4 precursor
NM_009263.3 NP_033289.2 osteopontin isoform 4 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables extracellular matrix binding IDA
IDA: Inferred from direct assay
18757743 MGI
enables integrin binding IDA
IDA: Inferred from direct assay
22654117 MGI
Biological Process GO Annotation Evidence References Source
involved in bone mineralization IDA
IDA: Inferred from direct assay
12817751 MGI
involved in bone mineralization IMP
IMP: Inferred from mutant phenotype
12817751 MGI
involved in calcium ion homeostasis IDA
IDA: Inferred from direct assay
12817751 MGI
acts upstream of or within cellular response to fluid shear stress IDA
IDA: Inferred from direct assay
24841674 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
acts upstream of or within collecting duct development IMP
IMP: Inferred from mutant phenotype
17898038 MGI
acts upstream of or within intracellular calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
17898038 MGI
acts upstream of or within intracellular chloride ion homeostasis IMP
IMP: Inferred from mutant phenotype
17898038 MGI
acts upstream of or within intracellular phosphate ion homeostasis IMP
IMP: Inferred from mutant phenotype
17898038 MGI
acts upstream of or within intracellular sodium ion homeostasis IMP
IMP: Inferred from mutant phenotype
17898038 MGI
acts upstream of or within neutrophil chemotaxis IDA
IDA: Inferred from direct assay
21321126 MGI
acts upstream of or within neutrophil chemotaxis IGI
IGI: Inferred from genetic interaction
21321126 MGI
acts upstream of or within positive regulation of cell-substrate adhesion IDA
IDA: Inferred from direct assay
18757743 MGI
acts upstream of or within urate biosynthetic process IMP
IMP: Inferred from mutant phenotype
17898038 MGI
Cellular Component GO Annotation Evidence References Source
located in apical part of cell IDA
IDA: Inferred from direct assay
16518820 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
16518820 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

osteopontin

  • 44 kDa bone phosphoprotein

  • bone sialoprotein 1

  • calcium oxalate crystal growth inhibitor protein

  • early T-lymphocyte activation 1 protein

  • minopontin

  • osteopontin-like protein

Recombinant Spp1 Proteins

Cat. No. Product Name Accession Purity
HY-P71786 Osteopontin/OPN Protein, Mouse (P.pastoris, His) P10923 (L17-S290) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P78358 Osteopontin/OPN Protein, Mouse (HEK293, His) P10923 (L17-N294) ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108009A Rezafungin acetate Inhibitor 99.84% Yes
HY-108009 Rezafungin Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-104029 Olorofim Inhibitor 99.38% Phase 3

Pre-clinical Phase

Bioactive Molecules (30)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-B2060A Tiamulin fumarate Inhibitor 99.27% Unkown
HY-113491 3-Phosphoglyceric acid 99.88% Unkown
HY-B2060 Tiamulin Inhibitor 99.74% Unkown
HY-RS13702 SPP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16219 SPP1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-126491 SPP-DM1 96.29% Unkown
HY-Y0760 3-Methoxybenzoic acid 99.61% Unkown
HY-N6695 Aflatoxicol 99.9% Unkown
HY-W019901B Anhydrous calcium sulfate (97%) Activator 99.40% Unkown
HY-P4613 Fmoc-D-allo-Thr-OH / Unkown
HY-136380 Clodinafop-propargyl 98.0% Unkown
HY-116479 Citromycetin Inhibitor 99.1% Unkown
HY-12613 2-C-methylene-myo-inositol oxide / Unkown
HY-139746 FPI-1602 Inhibitor / Unkown
HY-164207 VLPA-GlcNAc / Unkown
HY-N2340A D-(+)-Melezitose hydrate 98.0% Unkown
HY-N2728 6-O-Syringoylajugol / Unkown
HY-P0068 Aminocandin Inhibitor / Unkown
HY-P11187 Bactofencin A Inhibitor / Unkown
HY-RS03413 CXXC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12810 SGPP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W142497 3-Methyl-2(5H)-furanone 97.34% Unkown
HY-W766785 Tiamulin Fumarate-13C4 / Unkown
HY-Y0760R 3-Methoxybenzoic acid (Standard) / Unkown
HY-120729 Pyrazophos Inhibitor 99.52% Unkown
HY-B2060S1 Tiamulin-d10-1 hydrochloride Inhibitor / Unkown
HY-N11995 allo-Aloeresin D / Unkown
HY-N12882 (Z)-10-Hexadecen-1-ol / Unkown
HY-N15183 Aselacin C / Unkown
HY-RS22980 Spp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990117 Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10) Inhibitor 95.00% Unkown
HY-P990116 Anti-Mouse osteopontin/SPP1 Antibody (103D6) Inhibitor 99.91% Unkown
HY-P99140 Anti-Mouse IL-1R Antibody (JAMA-147) Inhibitor 95.00% Unkown
HY-P990795 Anti-Mouse osteopontin/SPP1 Antibody (100D3) Inhibitor 95% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spp1 NCBI NCBI:6696