2. Gene
  3. Pde2a - phosphodiesterase 2A, cGMP-stimulated Gene

Pde2a - phosphodiesterase 2A, cGMP-stimulated Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as cGSPDE; CGS-PDE

Gene ID: 207728 | Gene type: protein coding

About Pde2a

Chromosome 7: 101,060,093-101,162,026 forward strand.GRCm39:CM001000.3

This gene has 1 transcript (splice variant). Broad expression in adrenal adult (RPKM 43.4), cortex adult (RPKM 43.1) and 24 other tissues.

Summary

Enables several functions, including 3',5'-cyclic-nucleotide phosphodiesterase activity; GAF domain binding activity; and cyclic nucleotide binding activity. Involved in several processes, including cGMP catabolic process; cyclic-nucleotide-mediated signaling; and negative regulation of intracellular signal transduction. Acts upstream of or within cellular response to lipopolysaccharide; circulatory system development; and regulation of nitric oxide mediated signal transduction. Located in several cellular components, including mitochondrion; perinuclear region of cytoplasm; and presynaptic membrane. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system; nervous system; and sensory organ. Orthologous to human PDE2A (phosphodiesterase 2A). [provided by Alliance of Genome Resources, Apr 2022]

Pde2a Products(5)

mRNA Protein Name
NM_001008548.5 NP_001008548.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3
NM_001143848.3 NP_001137320.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 6
NM_001243757.2 NP_001230686.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A1
NM_001143849.3 NP_001137321.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A2 precursor
NM_001243758.2 NP_001230687.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 5

Pde2a Protein Structure

GAF

GAF: smart00065 (234 - 385)

GAF

GAF: smart00065 (407 - 556)

PDEase_I

PDEase_I: pfam00233 (653 - 886)

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  • 939 a.a.
Protein Preferred Names Protein Names

cGMP-dependent 3',5'-cyclic phosphodiesterase

cyclic GMP-stimulated phosphodiesterase

Related Agents

Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-112831 Osoresnontrine Inhibitor 99.88% Phase 2
HY-111371 PF-05180999 Inhibitor 99.97% Phase 1
HY-103493 TAK-915 Inhibitor 99.74% Phase 1
Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-102050 PF-05085727 Inhibitor 99.60% Unkown
HY-132993 Hcyb1 Inhibitor 98.24% Unkown
HY-112704 PDE5-IN-2 Inhibitor / Unkown
HY-142660 PDE2A-IN-1 Inhibitor / Unkown
HY-RS10213 PDE2A Human Pre-designed siRNA Set A / Unkown
HY-RS10214 Pde2a Mouse Pre-designed siRNA Set A / Unkown
HY-RS10215 Pde2a Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pde2a NCBI NCBI:5138