Strap - serine/threonine kinase receptor associated protein Gene

Also Known as Unrip

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20901

Summary

Enables U2 snRNP binding activity; mRNA binding activity; and signaling receptor binding activity. Involved in alternative mRNA splicing, via spliceosome; neuron differentiation; and ribonucleoprotein complex assembly. Acts upstream of or within negative regulation of transcription by RNA polymerase II and negative regulation of transforming growth factor beta receptor signaling pathway. Located in nucleus. Is expressed in several structures, including alimentary system; branchial arch; metanephros; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in adenocarcinoma; colorectal carcinoma; large cell carcinoma; lung carcinoma; and squamous cell neoplasm. Orthologous to human STRAP (serine/threonine kinase receptor associated protein). [provided by Alliance of Genome Resources, Apr 2022]

Strap Products (1)

mRNA Protein Name
NM_011499.3 NP_035629.2 serine-threonine kinase receptor-associated protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables U2 snRNP binding IDA
IDA: Inferred from direct assay
33230114 MGI
enables mRNA binding IDA
IDA: Inferred from direct assay
33230114 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9856985 MGI
enables signaling receptor binding IDA
IDA: Inferred from direct assay
9856985 MGI
Biological Process GO Annotation Evidence Verweise Source
involved in alternative mRNA splicing, via spliceosome IMP
IMP: Inferred from mutant phenotype
33230114 MGI
involved in anatomical structure development IMP
IMP: Inferred from mutant phenotype
33230114 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9856985 MGI
acts upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
9856985 MGI
involved in neuron differentiation IMP
IMP: Inferred from mutant phenotype
29781215 MGI
involved in protein-RNA complex assembly IMP
IMP: Inferred from mutant phenotype
33230114 MGI
Cellular Component GO Annotation Evidence Verweise Source
is active in nucleus IDA
IDA: Inferred from direct assay
33230114 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine-threonine kinase receptor-associated protein

  • UNR-interacting protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS13761 SRFBP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13961 STRAP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15216 TTC5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19745 Strap Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26242 Strap Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Strap NCBI NCBI:11171