Tle1 - transducin-like enhancer of split 1 Gene

Also Known as Grg1; Grg-1; Tle4l; Estm14; C230057C06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21885

Summary

Enables chromatin binding activity and transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human TLE1 (TLE family member 1, transcriptional corepressor). [provided by Alliance of Genome Resources, Apr 2022]

Tle1 Products (5)

mRNA Protein Name
NM_001285529.1 NP_001272458.1 transducin-like enhancer protein 1 isoform b
NM_001285530.1 NP_001272459.1 transducin-like enhancer protein 1 isoform c
NM_001285531.1 NP_001272460.1 transducin-like enhancer protein 1 isoform d
NM_001285532.1 NP_001272461.1 transducin-like enhancer protein 1 isoform e
NM_011599.5 NP_035729.3 transducin-like enhancer protein 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
16002402 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12359720 MGI
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
15528197 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12359720 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15528197 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15528197 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
12359720 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
15528197 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transducin-like enhancer protein 1

  • groucho-related protein 1

  • transducin-like enhancer of split 1, homolog of Drosophila E(spl)

  • transducin-like enhancer of split 4 (homolog of Drosophila E(spl)) - like

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS21443 Tle1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14563 TLE1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P10488 cycFWRPW Activator / Unkown
HY-RS27961 Tle1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tle1 NCBI NCBI:7088