MED19 - mediator complex subunit 19 Gene

Also Known as LCMR1; DT2P1G7; MED19AS

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 219541

About MED19

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:57,703,709-57,712,215 (from NCBI)

This gene has 5 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in testis (RPKM 7.0), brain (RPKM 5.0) and 25 other tissues.

Summary

The protein encoded by this gene is a subunit of the Mediator complex, which binds to gene-specific regulatory factors and provides support for the basal RNA polymerase II transcription machinery. This gene has been implicated in the growth of several types of Cancer, and inhibition of its expression inhibits the growth and spread of these cancers. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

MED19 Products (2)

mRNA Protein Name
NM_001317078.4 NP_001304007.2 mediator of RNA polymerase II transcription subunit 19 isoform 1
NM_153450.4 NP_703151.3 mediator of RNA polymerase II transcription subunit 19 isoform 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14576168 GOA
Cellular Component GO Annotation Evidence References Source
part of core mediator complex IPI
IPI: Inferred from physical interaction
24882805 GOA
located in nucleus IDA
IDA: Inferred from direct assay
24882805 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MED19 Protein Structure

Med19

Med19: Mediator of RNA pol II transcription subunit 19 (63 - 190)

  • 0
  • 100
  • 194 a.a.
Protein Preferred Names Protein Names

mediator of RNA polymerase II transcription subunit 19

  • lung cancer metastasis-related protein 1

MED19 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MED19 A0JLT2 MED29 Homo sapiens Q9NX70
Anti Tag CoIP
14576168
Intra
MED19 A0JLT2 MED29 Homo sapiens Q9NX70
Anti Tag CoIP
14638676
Intra
MED19 A0JLT2 MED29 Homo sapiens Q9NX70
Anti Tag CoIP
33961781
Intra
MED19 A0JLT2 MED29 Homo sapiens Q9NX70
Anti Tag CoIP
15175163
Intra
MED19 A0JLT2 MED29 Homo sapiens Q9NX70
Anti Tag CoIP
21729782
Intra
MED19 A0JLT2 MED29 Homo sapiens Q9NX70
Anti Tag CoIP
24882805
Intra
MED19 A0JLT2 MED29 Homo sapiens Q9NX70
Anti Tag CoIP
35271311
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lipodystrophy, Familial Partial, Type 5

  • FPLD5

  • Cidec-Related Familial Partial Lipodystrophy

  • Familial Partial Lipodystrophy Type 5

  • Cidec-Related Fpld

  • Familial Partial Lipodystrophy Associated With Cidec Mutations

  • Lipodystrophy, Familial Partial, Associated With Cidec Mutations

  • Lipodystrophy, Familial Partial, 5
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08290 MED19 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22631 Med19 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29146 Med19 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MED19 VGNC VGNC:31356
Mus musculus MED19 MGD MGI:1914234
Macaca mulatta MED19 VGNC VGNC:74615
Rattus norvegicus MED19 RGD RGD:1311926
Felis catus MED19 VGNC VGNC:103134
Canis familiaris MED19 VGNC VGNC:43128
Others MED19 NCBI