Tph1 - tryptophan hydroxylase 1 Gene

Also Known as Tph

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21990

Summary

This gene encodes a member of the biopterin-dependent aromatic amino acid hydroxylase family. The encoded protein is one of two Tryptophan Hydroxylase enzymes that catalyze the first and rate limiting step in the biosynthesis of the hormone and neurotransmitter, serotonin. This gene is expressed in peripheral organs, while Tryptophan Hydroxylase 2 is expressed in neurons. The encoded protein is involved in the development of hypoxia-induced elevations in pulmonary pressures and pulmonary vascular remodeling, and has also been implicated as a regulator of immune tolerance. Disruption of this gene is associated with cardiac dysfunction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]

Tph1 Products (3)

mRNA Protein Name
NM_001136084.2 NP_001129556.1 tryptophan 5-hydroxylase 1 isoform 1
NM_001276372.1 NP_001263301.1 tryptophan 5-hydroxylase 1 isoform 2
NM_009414.3 NP_033440.1 tryptophan 5-hydroxylase 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables tryptophan 5-monooxygenase activity IDA
IDA: Inferred from direct assay
2110547 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within bone remodeling IGI
IGI: Inferred from genetic interaction
19041748 MGI
acts upstream of or within mammary gland alveolus development IMP
IMP: Inferred from mutant phenotype
14960274 MGI
involved in platelet degranulation IMP
IMP: Inferred from mutant phenotype
14697203 MGI
acts upstream of or within positive regulation of fat cell differentiation IMP
IMP: Inferred from mutant phenotype
20719859 MGI
involved in regulation of hemostasis IMP
IMP: Inferred from mutant phenotype
14697203 MGI
involved in serotonin biosynthetic process IMP
IMP: Inferred from mutant phenotype
14697203 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
23500099 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tryptophan 5-hydroxylase 1

  • tryptophan 5-monooxygenase 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-101124 Rodatristat ethyl Inhibitor 99.82% Phase 2
HY-120083 Rodatristat Inhibitor 98.41% Phase 2

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W019599 4-Chloro-L-phenylalanine Inhibitor 98.19% Unkown
HY-157014 TPT-004 Inhibitor 99.90% Unkown
HY-RS14932 TPH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-156093 TPH1-IN-1 Inhibitor / Unkown
HY-RS17127 Tph1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23572 Tph1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tph1 NCBI NCBI:7166