Trh - thyrotropin releasing hormone Gene

Also Known as Trf; Pro-TRH

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22044

Summary

This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The mouse proprotein contains five thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as Prolactin. Disruption of this gene results in hypothyroidism, elevated thyroid-stimulating hormone levels, and hyperglycemia. [provided by RefSeq, Apr 2013]

Trh Products (1)

mRNA Protein Name
NM_009426.3 NP_033452.2 thyrotropin releasing hormone preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11181534 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adult walking behavior IGI
IGI: Inferred from genetic interaction
8719807 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

thyrotropin releasing hormone

  • TSH-releasing factor

  • pro-thyrotropin-releasing hormone

  • prothyroliberin

  • protirelin

  • thyrotropin-releasing factor

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0596 Taltirelin 99.91% Unkown
HY-P0002 Protirelin Activator 99.98% Unkown
HY-P0002A Protirelin acetate Activator 99.87% Yes
HY-B0596A Taltirelin acetate 99.75% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-106744 Azetirelin / Phase 3
HY-19154 Montirelin / Phase 2

Pre-clinical Phase

Bioactive Molecules (23)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-Y0973 BOP hexafluorophosphate ≥99.0% Unkown
HY-W009673 Boc-Pyr-OH 99.69% Unkown
HY-P3960 (Glu2)-TRH Inhibitor 99.96% Unkown
HY-P1213 JKC363 Antagonist 99.06% Unkown
HY-P10485 Glp-Asn-Pro-AMC 99.26% Unkown
HY-107380A PGlu-3-methyl-His-Pro-NH2 TFA 99.69% Unkown
HY-15113A Y-29794 tosylate Inhibitor 99.86% Unkown
HY-117178 TA 0910 acid-type Control 99.85% Unkown
HY-118117 Rovatirelin / Unkown
HY-15113 Y-29794 Inhibitor / Unkown
HY-B0596S Taltirelin-13C,d3 / Unkown
HY-P1213A JKC363 TFA Antagonist / Unkown
HY-P3962 [Phe2]-TRH / Unkown
HY-P3964 TRH Precursor Peptide / Unkown
HY-P3969 Prepro-TRH-(160-169) Agonist / Unkown
HY-P4367 TRH-AMC / Unkown
HY-P4584 TRH-βNA / Unkown
HY-RS15011 TRH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W345393 Trh-gly Agonist / Unkown
HY-122353 Orotirelin / Unkown
HY-136800 Posatirelin Inhibitor / Unkown
HY-RS16699 Trh Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23133 Trh Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trh NCBI NCBI:7200