Tob1 - transducer of ErbB-2.1 Gene

Also Known as Tob; Trob

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22057

Summary

Enables SMAD binding activity and transcription corepressor activity. Acts upstream of or within negative regulation of BMP signaling pathway; negative regulation of osteoblast differentiation; and regulation of SMAD protein signal transduction. Located in cytoplasm. Is expressed in 1st branchial arch; genitourinary system; limb; sensory organ; and skeleton. Orthologous to human TOB1 (transducer of ERBB2, 1). [provided by Alliance of Genome Resources, Apr 2022]

Tob1 Products (1)

mRNA Protein Name
NM_009427.2 NP_033453.2 protein Tob1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SMAD binding IDA
IDA: Inferred from direct assay
11163184 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11163184 MGI
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
11163184 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of BMP signaling pathway IDA
IDA: Inferred from direct assay
11163184 MGI
acts upstream of or within negative regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
11163184 MGI
acts upstream of or within regulation of SMAD protein signal transduction IDA
IDA: Inferred from direct assay
11163184 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11163184 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein Tob1

  • transducer of erbB2

Tob1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Tob1 Q61471 CORO7 Homo sapiens P57737
Y2H
21130766
Cross
Tob1 Q61471 CORO7 Homo sapiens P57737
IF
21130766
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14872 TOB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tob1 NCBI NCBI:10140