CORO7 - coronin 7 Gene

Also Known as CRN7; POD1; 0610011B16Rik

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79585

About CORO7

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:4,354,542-4,416,596 (from NCBI)

This gene has 33 transcripts (splice variants), 1 gene allele, 200 orthologues and 6 paralogues. Broad expression in bone marrow (RPKM 25.2), spleen (RPKM 18.8) and 24 other tissues.

Summary

This gene encodes a member of the coronin protein family. However, unlike Other coronin proteins, it is not an actin-binding protein but rather functions as an F-actin regulator directing anterograde Golgi to endosome transport. The encoded protein has two tandem WD-40 domain repeats and localizes to the trans-Golgi network. The protein undergoes K33-linked polyubiquitination via an E3 Ligase complex. It is thought to play an essential role in maintenance of Golgi apparatus morphology. Alternative splicing results in multiple transcripts variants; some of which form read-through transcripts with a neighboring gene. [provided by RefSeq, Dec 2016]

CORO7 Products (4)

mRNA Protein Name
NM_001201472.2 NP_001188401.1 coronin-7 isoform 2
NM_001201473.2 NP_001188402.1 coronin-7 isoform 3
NM_001351729.2 NP_001338658.1 coronin-7 isoform 4
NM_024535.5 NP_078811.3 coronin-7 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin binding IDA
IDA: Inferred from direct assay
24768539 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21130766 GOA
Biological Process GO Annotation Evidence References Source
involved in Golgi to endosome transport IMP
IMP: Inferred from mutant phenotype
24768539 GOA
involved in actin filament polymerization IMP
IMP: Inferred from mutant phenotype
24768539 GOA
involved in positive regulation of hippo signaling IMP
IMP: Inferred from mutant phenotype
33162394 GOA
Cellular Component GO Annotation Evidence References Source
located in trans-Golgi network IDA
IDA: Inferred from direct assay
24768539 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CORO7 Protein Structure

WD40

WD40: WD domain, G-beta repeat (70 - 105)

WD40

WD40: WD domain, G-beta repeat (159 - 196)

Trimer_CC

Trimer_CC: Trimerisation motif (252 - 385)

WD40

WD40: WD domain, G-beta repeat (543 - 572)

WD40

WD40: WD domain, G-beta repeat (586 - 623)

WD40

WD40: WD domain, G-beta repeat (632 - 664)

Trimer_CC

Trimer_CC: Trimerisation motif (721 - 857)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 925 a.a.
Protein Preferred Names Protein Names

coronin-7

  • 70 kDa WD repeat tumor rejection antigen homolog

CORO7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
CORO7 P57737 Tob1 Mus musculus Q61471
Anti Tag CoIP
21130766
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03053 CORO7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CORO7 RGD RGD:621591
Mus musculus CORO7 MGD MGI:1926135