Ctr9 - CTR9 homolog, Paf1/RNA polymerase II complex component Gene

Also Known as Tsp; Tsbp; Sh2bp1; mKIAA0155

Species: Mus musculus

Gene Type: protein coding

Gene ID: 22083

Summary

Enables SH2 domain binding activity. Involved in several processes, including cell surface receptor signaling pathway; histone H3-K4 trimethylation; and positive regulation of histone H3-K4 methylation. Acts upstream of or within blastocyst development and regulation of genetic imprinting. Located in nucleus and transcriptionally active chromatin. Part of Cdc73/Paf1 complex. Is expressed in cerebral cortex. Orthologous to human CTR9 (CTR9 homolog, Paf1/RNA polymerase II complex component). [provided by Alliance of Genome Resources, Apr 2022]

Ctr9 Products (1)

mRNA	Protein	Name
NM_009431.2	NP_033457.2	RNA polymerase-associated protein CTR9 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SH2 domain binding	IDA IDA: Inferred from direct assay	8636124	MGI
contributes to protein binding	IPI IPI: Inferred from physical interaction	27749823	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8636124	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within blastocyst growth	IGI IGI: Inferred from genetic interaction	24036311	MGI
acts upstream of or within blastocyst growth	IMP IMP: Inferred from mutant phenotype	24036311	MGI
acts upstream of or within blastocyst hatching	IMP IMP: Inferred from mutant phenotype	27869233	MGI
involved in cell surface receptor signaling pathway via JAK-STAT	IMP IMP: Inferred from mutant phenotype	17911113	MGI
involved in cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	17911113	MGI
involved in chromatin organization	IMP IMP: Inferred from mutant phenotype	19345177	MGI
involved in endodermal cell fate commitment	IMP IMP: Inferred from mutant phenotype	19345177	MGI
acts upstream of or within inner cell mass cell differentiation	IMP IMP: Inferred from mutant phenotype	24036311	MGI
involved in interleukin-6-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	17911113	MGI
acts upstream of or within negative regulation of gene expression, epigenetic	IMP IMP: Inferred from mutant phenotype	24036311	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19345177	MGI
involved in stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	19345177	MGI
acts upstream of or within trophectodermal cell differentiation	IMP IMP: Inferred from mutant phenotype	24036311	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of Cdc73/Paf1 complex	IPI IPI: Inferred from physical interaction	27749823	MGI
located in euchromatin	IDA IDA: Inferred from direct assay	19345177	MGI
located in nucleus	IDA IDA: Inferred from direct assay	8636124	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
RNA polymerase-associated protein CTR9 homolog	Ctr9, Paf1/RNA polymerase II complex component, homolog SH2 domain binding protein 1 (tetratricopeptide repeat containing) SH2 domain-binding protein 1 TPR-containing, SH2-binding phosphoprotein of 150 kDa p150TSP tetratricopeptide repeat-containing,

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-160267	iPAF1C		99.59%	Unkown
HY-RS03316	CTR9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22131	Ctr9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28653	Ctr9 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ctr9	NCBI	NCBI:9646