Vcl - vinculin Gene

Also Known as 9430097D22

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22330

Summary

Predicted to enable alpha-catenin binding activity; dystroglycan binding activity; and enzyme binding activity. Acts upstream of or within cell adhesion; plasma membrane bounded cell projection organization; and regulation of cell migration. Located in several cellular components, including costamere; fascia adherens; and focal adhesion. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and yolk sac. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1W; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 15. Orthologous to human VCL (vinculin). [provided by Alliance of Genome Resources, Apr 2022]

Vcl Products (1)

mRNA Protein Name
NM_009502.5 NP_033528.3 vinculin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10085297 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within axon extension IGI
IGI: Inferred from genetic interaction
24623780 MGI
acts upstream of or within cell adhesion IDA
IDA: Inferred from direct assay
12473693 MGI
acts upstream of or within lamellipodium assembly IDA
IDA: Inferred from direct assay
12473693 MGI
acts upstream of or within regulation of cell migration IDA
IDA: Inferred from direct assay
12473693 MGI
Cellular Component GO Annotation Evidence References Source
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
21048959 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
14657280 MGI
located in costamere IDA
IDA: Inferred from direct assay
15128702 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
24036928 MGI
located in fascia adherens IDA
IDA: Inferred from direct assay
11732910 MGI
located in focal adhesion IDA
IDA: Inferred from direct assay
12711699 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16481394 MGI
located in podosome IDA
IDA: Inferred from direct assay
17893324 MGI
located in podosome ring IDA
IDA: Inferred from direct assay
27505886 MGI
located in sarcolemma IDA
IDA: Inferred from direct assay
26359501 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vinculin

  • metavinculin

Recombinant Vcl Proteins

Cat. No. Product Name Accession Purity
HY-P73549 Vinculin Protein, Mouse (HEK293, His) Q64727 (M1-Q1066) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15620 VCL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19870 Vcl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26369 Vcl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vcl NCBI NCBI:7414