VCL - vinculin Gene

Also Known as MV; MVCL; CMD1W; CMH15; HEL114

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7414

About VCL

Cytogenetic location: 10q22.2 Genomic coordinates (GRCh38): 10:73,998,116-74,121,363 (from NCBI)

This gene has 7 transcripts (splice variants), 284 orthologues, 4 paralogues and is associated with 4 phenotypes. Ubiquitous expression in endometrium (RPKM 87.7), prostate (RPKM 70.2) and 25 other tissues.

Summary

Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

VCL Products (2)

mRNA	Protein	Name
NM_003373.4	NP_003364.1	vinculin isoform VCL
NM_014000.3	NP_054706.1	vinculin isoform meta-VCL

VCL Protein Structure

Vinculin

0
200
400
600
800
1000
1134 a.a.

Protein Preferred Names	Protein Names
vinculin	epididymis luminal protein 114

VCL Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	VCL	P18206	TEKT1	Homo sapiens	Q969V4	Y2H Array	25416956
Intra	VCL	P18206	ARPC2	Homo sapiens	O15144	Anti Bait CoIP	12473693
Cross	VCL	P18206	ipaA	Shigella flexneri	Q6XVZ2	X-Ray Diffraction	16826238
Cross	VCL	P18206	ipaA	Shigella flexneri	Q6XVZ2	GMS	16826238
Intra	VCL	P18206	ABI2	Homo sapiens	Q9NYB9	Y2H Pooling	16189514
Intra	VCL	P18206	ABI2	Homo sapiens	Q9NYB9	Y2H Array	29892012
Cross	VCL	P18206	ipaA	Shigella flexneri	P18010	Solid Phase Assay	17932491
Cross	VCL	P18206	ipaA	Shigella flexneri	P18010	X-Ray Diffraction	21525010
Cross	VCL	P18206	ipaA	Shigella flexneri	P18010	BN-PAGE	21525010
Cross	VCL	P18206	b0bxr4_ricro	Rickettsia rickettsii	B0BXR4	Comig Non-Denat Gel	21841197

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant VCL Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70994	Vinculin Protein, Human	AAH39174.1 (P2-Q1066)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P71693	Vinculin Protein, Human (GST)	P18206 (P2-E235)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P73550	Vinculin Protein, Human (HEK293, His)	P18206-2 (M1-Q1066)	≥ 90%, as determined by reducing SDS-PAGE.

VCL Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80372	Vinculin Antibody (YA010)	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P85789	Vinculin Antibody (YA5481)	IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
HY-P85825	Vinculin Antibody (YA5517)	WB, ICC/IF, ELISA	Human, Mouse, Rat
HY-P86205	Vinculin Antibody (YA5897)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Cardiomyopathy, Familial Hypertrophic, 15	Hypertrophic Cardiomyopathy 15 CMH15 Cardiomyopathy, Hypertrophic, 15 Cardiomyopathy Familial Hypertrophic 15 Cardiomyopathy, Familial Hypertrophic 15 Cardiomyopathy, Hypertrophic, Familial, Type 15
Cardiomyopathy, Dilated, 1w	CMD1W Dilated Cardiomyopathy 1w Cardiomyopathy, Dilated 1w Cardiomyopathy, Dilated, Type 1w
Familial Isolated Dilated Cardiomyopathy	Familial Or Idiopathic Dilated Cardiomyopathy
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Congestive Heart Failure	Congestive Heart Disease Heart Failure Cardiac Failure Congestive Chf Weak Heart Heart Failure Congestive Ccf - [Congestive Cardiac Failure] Chf - [Congestive Heart Failure] Congestive Cardiac Diseases Congested Heart Failure Congestive Cardiac Failure Cardiac Anasarca Cardiac Oedema Cardiac Stasis Cardiovascular Oedema Cardiac Hydrops Congestive Failure Heart Congestion Heart Fluid Oedematous Heart
Quebec Platelet Disorder	Factor V Quebec QPD Bdplt5 Bleeding Disorder, Platelet-Type, 5 Platelet-Type Bleeding Disorder 5 Bleeding Disorder Platelet-Type 5 Platelet Disorder, Quebec
Muscular Dystrophy, Becker Type	Becker Muscular Dystrophy BMD Benign Pseudohypertrophic Muscular Dystrophy Benign Congenital Myopathy Becker Dystrophinopathy Becker'S Muscular Dystrophy Muscular Dystrophy, Pseudohypertrophic Progressive, Becker Type Muscular Dystrophy Pseudohypertrophic Progressive, Becker Type Muscular Dystrophy Becker Dystrophy, Muscular, Becker Type Dystrophinopathy Becker Dystrophy Becker Type Dystrophy Bmd - [Becker Muscular Dystrophy]
Shigellosis	Dysentery, Bacillary Bacillary Dysentery Shigella Boydii Infectious Disease Shigella Flexneri Infectious Disease Shigella Gastroenteritis Shigella Sonnei Infectious Disease Shigella Infections
Darier-White Disease	Keratosis Follicularis Darier Disease Darier'S Disease DAR DD Darier White Disease Darier Disease Acral Hemorrhagic Type Darier Disease Segmental Darier Disease, Acral Hemorrhagic Type Darier Disease, Segmental
Xanthomatosis	Xanthomatosis, Susceptibility To Xanthelasmatosis
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos
Focal Segmental Glomerulosclerosis	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Focal Glomerulosclerosis Fsgs Segmental Glomerulosclerosis Glomerulosclerosis, Focal Segmental Fgs Focal Glomerular Sclerosis Familial Idiopathic Nephrotic Syndrome Focal Sclerosis With Hyalinosis Glomerulosclerosis, Focal Glomerulosclerosis Focal Glomerulosclerosis, Segmental, Focal Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Developmental And Epileptic Encephalopathy 38	DEE38 Epileptic Encephalopathy, Early Infantile, 38 Eiee38 Developmental And Epileptic Encephalopathy, 38 Glycosylphosphatidylinositol Biosynthesis Defect 23 Gpibd23 Early Infantile Epileptic Encephalopathy 38
Muscular Dystrophy	Muscular Dystrophies Congenital Md Congenital Muscular Dystrophy Cmd Mdc Dystrophy, Muscular Gower'S Muscular Dystrophy Progressive Musclular Dystrophy Pseudohypertrophic Atrophy Pseudohypertrophic Muscle Paralysis Pseudohypertrophic Muscular Atrophy Pseudohypertrophic Muscular Dystrophy Pseudohypertrophic Paralysis Pseudomuscular Hypertrophy
Muscular Dystrophy, Duchenne Type	Duchenne Muscular Dystrophy DMD Muscular Dystrophy, Duchenne Muscular Dystrophy, Pseudohypertrophic Progressive, Duchenne Type Severe Dystrophinopathy, Duchenne Type Muscular Dystrophy Duchenne Dystrophy, Muscular, Duchenne Type Benign Duchenne Muscular Dystrophy Duchenne Motor Neuron Disease Duchenne Type Dystrophy Duchenne-Griesinger Disease
Colon Adenocarcinoma	Adenocarcinoma Of Colon Adenocarcinoma Of The Colon Colonic Adenocarcinoma
Parameningeal Embryonal Rhabdomyosarcoma
Neuromuscular Disease	Neuromuscular Diseases Neuromuscular Disorders Neuromuscular Disorder
Junctional Epidermolysis Bullosa	Epidermolysis Bullosa, Junctional Jeb Epidermolysis Bullosa Atrophicans Congenital Junctional Epidermolysis Bullosa Epidermolysis Bullosa Junctional Junctional Eb - [Epidermolysis Bullosa] Jeb - [Junctional Epidermolysis Bullosa] Lucidolytic Epidermolysis Bullosa
Hypertrophic Cardiomyopathy	Hypertrophic Obstructive Cardiomyopathy Cardiomyopathy, Hypertrophic Cardiomyopathy Hypertrophic Obstructive Cardiomyopathy, Hypertrophic, Familial Idiopathic Myocardial Hypertrophy Idiopathic Hypertrophic Cardiomyopathy Obstructive Idiopathic Hypertrophic Cardiomyopathy Obstructive Cardiomyopathy Idiopathic Hypertrophic Subaortic Stenosis Muscular Subaortic Stenosis Hypertrophic Obstructive Subaortic Stenosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15620	VCL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19870	Vcl Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26369	Vcl Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	VCL	VGNC	VGNC:106118
Felis catus	VCL	VGNC	VGNC:66932
Canis familiaris	VCL	VGNC	VGNC:48242
Bos taurus	VCL	VGNC	VGNC:36779
Rattus norvegicus	VCL	RGD	RGD:1311217
Mus musculus	VCL	MGD	MGI:98927
Others	VCL	NCBI