Kif18a - kinesin family member 18A Gene

Also Known as gcd2; B130001M12Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 228421

Summary

Predicted to enable several functions, including ATP hydrolysis activity; cytoskeletal protein binding activity; and plus-end-directed microtubule motor activity. Acts upstream of or within nuclear division; regulation of microtubule Cytoskeleton organization; and seminiferous tubule development. Located in kinetochore and mitotic spindle midzone. Is expressed in central nervous system; gonad; and retina. Orthologous to human KIF18A (Kinesin family member 18A). [provided by Alliance of Genome Resources, Apr 2022]

Kif18a Products (1)

mRNA Protein Name
NM_139303.1 NP_647464.1 kinesin-like protein KIF18A

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within male meiotic nuclear division IMP
IMP: Inferred from mutant phenotype
20981276 MGI
acts upstream of or within mitotic metaphase chromosome alignment IMP
IMP: Inferred from mutant phenotype
20981276 MGI
acts upstream of or within regulation of microtubule cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
20981276 MGI
acts upstream of or within seminiferous tubule development IMP
IMP: Inferred from mutant phenotype
20981276 MGI
Cellular Component GO Annotation Evidence References Source
located in kinetochore IDA
IDA: Inferred from direct assay
20981276 MGI
located in mitotic spindle midzone IDA
IDA: Inferred from direct assay
20981276 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

kinesin-like protein KIF18A

  • N-8 kinesin

  • kinesin superfamily protein 18A

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-132840 Sovilnesib Inhibitor 99.90% Phase 1

Pre-clinical Phase

Bioactive Molecules (25)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-153065 KIF18A-IN-6 Inhibitor 98.48% Unkown
HY-153066 VLS-1272 99.63% Unkown
HY-101770 BTB-1 Inhibitor 99.91% Unkown
HY-145034 KIF18A-IN-1 Inhibitor 98.06% Unkown
HY-162110 AM-9022 Inhibitor 99.53% Unkown
HY-144894 AM-5308 Inhibitor 99.15% Unkown
HY-162937 KIF18A-IN-13 Inhibitor 99.93% Unkown
HY-145802 KIF18A-IN-2 Inhibitor 98.49% Unkown
HY-145803 KIF18A-IN-3 Inhibitor 99.30% Unkown
HY-162531 KIF18A-IN-9 Inhibitor 95.03% Unkown
HY-RS07267 KIF18A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-145827 KIF18A-IN-4 Inhibitor / Unkown
HY-158683 KIF18A-IN-11 Inhibitor / Unkown
HY-158757 KIF18A-IN-12 Inhibitor / Unkown
HY-162110A (S)-AM-9022 Control 99.88% Unkown
HY-162532 KIF18A-IN-10 Inhibitor / Unkown
HY-162667 EX05 Inhibitor / Unkown
HY-164978 KIF18A-IN-14 Inhibitor / Unkown
HY-164979 KIF18A-IN-15 Inhibitor / Unkown
HY-164980 KIF18A-IN-16 Inhibitor / Unkown
HY-178511 KIF18A-IN-17 Inhibitor / Unkown
HY-180170 KIF18A-IN-18 Inhibitor / Unkown
HY-180641 KIF18A-IN-19 Inhibitor / Unkown
HY-RS16612 Kif18a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23047 Kif18a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kif18a NCBI NCBI:81930