MAST1 - microtubule associated serine/threonine kinase 1 Gene

Also Known as SAST; MCCCHCM

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22983

About MAST1

Cytogenetic location: 19p13.13 Genomic coordinates (GRCh38): 19:12,838,515-12,874,952 (from NCBI)

This gene has 9 transcripts (splice variants), 299 orthologues, 13 paralogues and is associated with 2 phenotypes. Biased expression in brain (RPKM 10.3), testis (RPKM 1.3) and 1 other tissue.

Summary

This gene is a member of the microtubule-associated serine/threonine kinase (MAST) family. The protein encoded by this gene has an N-terminal serine/threonine kinase domain followed by a postsynaptic density protein-95/discs large/zona occludens-1 (PDZ) domain. In mouse and rat, the orthologous protein associates with the Cytoskeleton and can bind both beta-2-syntrophin and neuronal nitric oxide synthase (nNOS) through its PDZ domain. In mouse and rat, this protein also co-localizes with dystrophin- and utrophin-associated protein complexes (DAPC/UAPC) in the vascular endothelium of the central nervous system. [provided by RefSeq, May 2017]

MAST1 Products (1)

mRNA Protein Name
NM_014975.3 NP_055790.1 microtubule-associated serine/threonine-protein kinase 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20029029 GOA
Biological Process GO Annotation Evidence References Source
involved in brain development IMP
IMP: Inferred from mutant phenotype
30449657 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAST1 Protein Structure

DUF1908

DUF1908: Domain of unknown function (DUF1908) (61 - 336)

Pkinase

Pkinase: Protein kinase domain (376 - 647)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (973 - 1050)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1570 a.a.
Protein Preferred Names Protein Names

microtubule-associated serine/threonine-protein kinase 1

  • syntrophin associated serine/threonine kinase

MAST1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MAST1 Q9Y2H9 EGFR Homo sapiens P00533
Ub Reconstruction
20029029
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Mega-Corpus-Callosum Syndrome With Cerebellar Hypoplasia And Cortical Malformations

  • MCCCHCM
Cerebellar Hypoplasia
Megalencephaly

  • Macroencephaly

  • Macrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02744 CLASP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08161 MAST1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22625 Mast1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MAST1 MGD MGI:1861901
Rattus norvegicus MAST1 RGD RGD:631372
Bos taurus MAST1 VGNC VGNC:31257
Macaca mulatta MAST1 VGNC VGNC:82182
Felis catus MAST1 VGNC VGNC:63393
Canis familiaris MAST1 VGNC VGNC:43032
Others MAST1 NCBI