2. Gene
  3. MAST1 - microtubule associated serine/threonine kinase 1 Gene

MAST1 - microtubule associated serine/threonine kinase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SAST; MCCCHCM

Gene ID: 22983 | Gene type: protein coding

About MAST1

Cytogenetic location: 19p13.13 Genomic coordinates (GRCh38): 19:12,838,515-12,874,952 (from NCBI)

This gene has 9 transcripts (splice variants), 299 orthologues, 13 paralogues and is associated with 2 phenotypes. Biased expression in brain (RPKM 10.3), testis (RPKM 1.3) and 1 other tissue.

Summary

This gene is a member of the microtubule-associated serine/threonine kinase (MAST) family. The protein encoded by this gene has an N-terminal serine/threonine kinase domain followed by a postsynaptic density protein-95/discs large/zona occludens-1 (PDZ) domain. In mouse and rat, the orthologous protein associates with the Cytoskeleton and can bind both beta-2-syntrophin and neuronal nitric oxide synthase (nNOS) through its PDZ domain. In mouse and rat, this protein also co-localizes with dystrophin- and utrophin-associated protein complexes (DAPC/UAPC) in the vascular endothelium of the central nervous system. [provided by RefSeq, May 2017]

MAST1 Products(1)

mRNA Protein Name
NM_014975.3 NP_055790.1 microtubule-associated serine/threonine-protein kinase 1

MAST1 Protein Structure

DUF1908

DUF1908: Domain of unknown function (DUF1908) (61 - 336)

Pkinase

Pkinase: Protein kinase domain (376 - 647)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (973 - 1050)

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  • 1570 a.a.
Protein Preferred Names Protein Names

microtubule-associated serine/threonine-protein kinase 1

syntrophin associated serine/threonine kinase

Related Diseases

Diseases Alias
Mega-Corpus-Callosum Syndrome With Cerebellar Hypoplasia And Cortical Malformations

MCCCHCM
Cerebellar Hypoplasia
Megalencephaly

Macroencephaly

Macrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08161 MAST1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MAST1 MGD MGI:1861901
Rattus norvegicus MAST1 RGD RGD:631372
Bos taurus MAST1 VGNC VGNC:31257
Macaca mulatta MAST1 VGNC VGNC:82182
Felis catus MAST1 VGNC VGNC:63393
Canis familiaris MAST1 VGNC VGNC:43032