STAB1 - stabilin 1 Gene

Also Known as FEX1; FEEL1; FEEL-1; FELE-1; SCARH2; STAB-1; CLEVER-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23166

About STAB1

Cytogenetic location: 3p21.1 Genomic coordinates (GRCh38): 3:52,495,338-52,524,495 (from NCBI)

This gene has 9 transcripts (splice variants), 196 orthologues and 2 paralogues. Broad expression in spleen (RPKM 55.7), placenta (RPKM 32.7) and 21 other tissues.

Summary

This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 16 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to endocytose ligands such as low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein rapidly cycles between the plasma membrane and early endosomes. [provided by RefSeq, Jul 2008]

STAB1 Products (1)

mRNA Protein Name
NM_015136.3 NP_055951.2 stabilin-1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables low-density lipoprotein particle binding IDA
IDA: Inferred from direct assay
12077138 GOA
enables low-density lipoprotein particle receptor activity IDA
IDA: Inferred from direct assay
12077138 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16357325 GOA
enables scavenger receptor activity IDA
IDA: Inferred from direct assay
12077138 GOA
Biological Process GO Annotation Evidence References Source
involved in cell-cell signaling IDA
IDA: Inferred from direct assay
12077138 GOA
involved in defense response to bacterium IDA
IDA: Inferred from direct assay
12077138 GOA
involved in negative regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
12077138 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
12077138 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STAB1 Protein Structure

Fasciclin

Fasciclin: Fasciclin domain (384 - 490)

Fasciclin

Fasciclin: Fasciclin domain (518 - 643)

EGF_3

EGF_3: EGF domain (913 - 945)

EGF_3

EGF_3: EGF domain (951 - 987)

Fasciclin

Fasciclin: Fasciclin domain (1000 - 1120)

Fasciclin

Fasciclin: Fasciclin domain (1140 - 1230)

EGF_3

EGF_3: EGF domain (1459 - 1495)

EGF_3

EGF_3: EGF domain (1501 - 1536)

Fasciclin

Fasciclin: Fasciclin domain (1606 - 1710)

Fasciclin

Fasciclin: Fasciclin domain (1737 - 1866)

EGF_3

EGF_3: EGF domain (2095 - 2130)

Xlink

Xlink: Extracellular link domain (2208 - 2300)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2400
  • 2570 a.a.
Protein Preferred Names Protein Names

stabilin-1

  • MS-1 antigen

STAB1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
STAB1 Q9NY15 FN1 Homo sapiens P02751
Y2H
34968453
Intra
STAB1 Q9NY15 FN1 Homo sapiens P02751
Pull Down
34968453
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Histiocytosis

  • Chronic Histiocytosis X

  • Hand Schuller Christian Disease

  • Hand-Schüller-Christian Disease

  • Histiocytic Syndrome

  • Histiocytosis, Langerhans-Cell
Chronic Kidney Disease

  • Chronic Renal Disease

  • Chronic Kidney Failure

  • Ckd

  • Chronic Renal Failure

  • Kidney Failure, Chronic

  • Chronic Renal Failure Syndrome

  • Crf

  • Renal Failure - Chronic

  • Renal Failure Chronic

  • Chronic Kidney Diseases

  • Chronic Kidney Disease Stage 5

  • Ckd - [Chronic Kidney Disease]

  • Crf - [Chronic Renal Failure]

  • Chronic Kidney Impairment

  • Chronic Renal Impairment

  • Chronic Kidney Shutdown

  • Chronic Hypoxic Kidney Failure

  • Chronic Kidney Collapse

  • Chronic Renal Insufficiency

  • Chronic Kidney Toxaemia

  • Chronic Kidney Hypofunction

  • Chronic Renal Suppression

  • Chronic Renal Failure, Stage 5

  • Ckd - [Chronic Kidney Disease] Stage 5

  • End Stage Kidney Failure

  • End Stage Renal Failure

  • End Stage Kidney Disease

  • End Stage Renal Disease

  • End Stage Chronic Renal Failure

  • Esrf - [End Stage Renal Failure]

  • Esrd - [End Stage Renal Diseases]

  • Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13861 STAB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus STAB1 MGD MGI:2178742
Rattus norvegicus STAB1 RGD RGD:2324745
Bos taurus STAB1 VGNC VGNC:35348
Macaca mulatta STAB1 VGNC VGNC:77956
Canis familiaris STAB1 VGNC VGNC:54368
Felis catus STAB1 VGNC VGNC:65739
Others STAB1 NCBI