PLCL2 - phospholipase C like 2 Gene

Also Known as PLCE2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23228

About PLCL2

Cytogenetic location: 3p24.3 Genomic coordinates (GRCh38): 3:16,884,955-17,090,606 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 226 orthologues and 14 paralogues. Ubiquitous expression in ovary (RPKM 4.0), lymph node (RPKM 3.4) and 23 other tissues.

Summary

Enables GABA Receptor binding activity. Predicted to be involved in negative regulation of cold-induced thermogenesis and phosphatidylinositol-mediated signaling. Predicted to act upstream of or within several processes, including B cell activation; gamma-aminobutyric acid signaling pathway; and negative regulation of B cell receptor signaling pathway. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PLCL2 Products (2)

mRNA Protein Name
NM_001144382.2 NP_001137854.1 inactive phospholipase C-like protein 2 isoform 1
NM_015184.5 NP_055999.2 inactive phospholipase C-like protein 2 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables GABA receptor binding IDA
IDA: Inferred from direct assay
16754670 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15231748 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLCL2 Protein Structure

EF-hand_like

EF-hand_like: Phosphoinositide-specific phospholipase C, efhand-like (217 - 299)

PI-PLC-X

PI-PLC-X: Phosphatidylinositol-specific phospholipase C, X domain (302 - 445)

PI-PLC-Y

PI-PLC-Y: Phosphatidylinositol-specific phospholipase C, Y domain (491 - 608)

C2

C2: C2 domain (630 - 719)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1001 a.a.
Protein Preferred Names Protein Names

inactive phospholipase C-like protein 2

  • PLC-L(2)

PLCL2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PLCL2 Q9UPR0 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
PLCL2 Q9UPR0 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
PLCL2 Q9UPR0 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
PLCL2 Q9UPR0 HRAS Homo sapiens P01112
Y2H Array
32814053
Intra
PLCL2 Q9UPR0 HRAS Homo sapiens P01112
Y2H Pooling
32814053
Intra
PLCL2 Q9UPR0 HRAS Homo sapiens P01112
Validated Y2H
32814053
Intra
PLCL2 Q9UPR0 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra
PLCL2 Q9UPR0 GSN Homo sapiens P06396
Y2H Array
32814053
Intra
PLCL2 Q9UPR0 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra
PLCL2 Q9UPR0 PPP1CA Homo sapiens P62136
Y2H
15231748
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spondylometaepiphyseal Dysplasia, Short Limb-Hand Type

  • Spondyloepimetaphyseal Dysplasia-Short Limb-Abnormal Calcification Syndrome

  • Smed-Sl

  • Smed-Sl/Ac

  • Smed Short Limb-Abnormal Calcification Type

  • Smed Short Limb-Hand Type

  • Spondylometaepiphyseal Dysplasia Short Limb-Hand Type

  • Smed, Type Ii

  • Smed Type 2

  • Spondylometaepiphyseal Dysplasia Short Limb-Abnormal Calcification Type

  • Smed, Short Limb-Hand Type

  • Spondylometaepiphyseal Dysplasia, Short Limb-Abnormal Calcification Type

  • Smed, Short Limb-Abnormal Calcification Type

  • Spondyloepimetaphyseal Dysplasia - Short Limb - Abnormal Calcification

  • Spondyloepimetaphyseal Dysplasia, Short Limb-Hand Type

  • SEMD-SL

  • Smed Type Ii

  • Dysplasia, Spondylometaepiphyseal, Short Limb-Hand Type
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10665 PLCL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PLCL2 RGD RGD:1305941
Mus musculus PLCL2 MGD MGI:1352756
Felis catus PLCL2 VGNC VGNC:68899
Canis familiaris PLCL2 VGNC VGNC:44655
Bos taurus PLCL2 VGNC VGNC:32992
Macaca mulatta PLCL2 VGNC VGNC:76168
Others PLCL2 NCBI