SCFD1 - sec1 family domain containing 1 Gene

Also Known as SLY1; RA410; SLY1P; STXBP1L2; C14orf163

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23256

About SCFD1

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:30,622,254-30,735,850 (from NCBI)

This gene has 72 transcripts (splice variants), 213 orthologues and 7 paralogues. Ubiquitous expression in thyroid (RPKM 19.4), testis (RPKM 13.5) and 25 other tissues.

Summary

Predicted to enable syntaxin binding activity. Involved in negative regulation of autophagosome assembly; regulation of protein transport; and response to toxic substance. Located in cis-Golgi network. [provided by Alliance of Genome Resources, Apr 2022]

SCFD1 Products (6)

mRNA Protein Name
NM_001257376.1 NP_001244305.1 sec1 family domain-containing protein 1 isoform c
NM_001283031.1 NP_001269960.1 sec1 family domain-containing protein 1 isoform d
NM_001283032.1 NP_001269961.1 sec1 family domain-containing protein 1 isoform e
NM_001283033.1 NP_001269962.1 sec1 family domain-containing protein 1 isoform d
NM_016106.4 NP_057190.2 sec1 family domain-containing protein 1 isoform a
NM_182835.2 NP_878255.1 sec1 family domain-containing protein 1 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19536132 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of autophagosome assembly IMP
IMP: Inferred from mutant phenotype
21242315 GOA
involved in regulation of protein transport IMP
IMP: Inferred from mutant phenotype
21242315 GOA
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
15649705 GOA
Cellular Component GO Annotation Evidence References Source
located in cis-Golgi network IDA
IDA: Inferred from direct assay
15649705 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCFD1 Protein Structure

Sec1

Sec1: Sec1 family (43 - 636)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 642 a.a.
Protein Preferred Names Protein Names

sec1 family domain-containing protein 1

  • syntaxin-binding protein 1-like 2

SCFD1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SCFD1 Q8WVM8 COG4 Homo sapiens Q9H9E3
Pull Down
19536132
Intra
SCFD1 Q8WVM8 COG4 Homo sapiens Q9H9E3
Anti Tag CoIP
19536132
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Familial Adenomatous Polyposis 3

  • FAP3

  • Nthl1-Related Attenuated Familial Adenomatous Polyposis

  • Nthl1-Related Afap

  • Nthl1-Related Attenuated Fap
Achondrogenesis, Type Ia

  • Achondrogenesis Type Ia

  • Achondrogenesis Type 1a

  • ACG1A

  • Achondrogenesis, Houston-Harris Type

  • Achondrogenesis Houston-Harris Type

  • Achondrogenesis 1a

  • Acg-Ia
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12499 SCFD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SCFD1 VGNC VGNC:64907
Rattus norvegicus SCFD1 RGD RGD:619828
Bos taurus SCFD1 VGNC VGNC:34330
Mus musculus SCFD1 MGD MGI:1924233
Macaca mulatta SCFD1 VGNC VGNC:77065
Canis familiaris SCFD1 VGNC VGNC:45903
Others SCFD1 NCBI