FKBP15 - FKBP prolyl isomerase family member 15 Gene

Also Known as FKBP133; PPP1R76; KIAA0674

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23307

About FKBP15

Cytogenetic location: 9q32 Genomic coordinates (GRCh38): 9:113,161,006-113,221,277 (from NCBI)

This gene has 23 transcripts (splice variants), 210 orthologues, 18 paralogues and is associated with 1 phenotype. Ubiquitous expression in spleen (RPKM 13.2), appendix (RPKM 13.2) and 25 other tissues.

Summary

Predicted to enable actin binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in endocytosis and protein peptidyl-prolyl isomerization. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

FKBP15 Products (1)

mRNA Protein Name
NM_015258.2 NP_056073.1 FK506-binding protein 15

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20923837 GOA
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
22070227 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FKBP15 Protein Structure

FKBP_C

FKBP_C: FKBP-type peptidyl-prolyl cis-trans isomerase (193 - 286)

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  • 1219 a.a.
Protein Preferred Names Protein Names

FK506-binding protein 15

  • 133 kDa FK506-binding protein

FKBP15 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
FKBP15 Q5T1M5 Vps35 Mus musculus Q9EQH3
Y2H
20923837
Cross
FKBP15 Q5T1M5 Vps29 Mus musculus Q9QZ88
Density Sedimentation
20923837
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04959 FKBP15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus FKBP15 MGD MGI:2444782
Macaca mulatta FKBP15 VGNC VGNC:72557
Bos taurus FKBP15 VGNC VGNC:29020
Rattus norvegicus FKBP15 RGD RGD:1304816
Felis catus FKBP15 VGNC VGNC:62279
Canis familiaris FKBP15 VGNC VGNC:40888
Others FKBP15 NCBI