Fus - fused in sarcoma Gene

Also Known as Tls; Fus1; D430004D17Rik; D930039C12Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 233908

Summary

Enables mRNA 3'-UTR binding activity. Acts upstream of or within RNA splicing. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and lung. Used to study amyotrophic lateral sclerosis type 6. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 6; essential tremor 4; liposarcoma; and neurodegenerative disease. Orthologous to human FUS (FUS RNA binding protein). [provided by Alliance of Genome Resources, Apr 2022]

Fus Products (2)

mRNA Protein Name
NM_001347649.1 NP_001334578.1 RNA-binding protein FUS isoform 2
NM_139149.2 NP_631888.1 RNA-binding protein FUS isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
27378374 MGI
enables mRNA 3'-UTR binding IDA
IDA: Inferred from direct assay
27378374 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23681068 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within RNA splicing IMP
IMP: Inferred from mutant phenotype
27378374 MGI
acts upstream of or within gene expression IGI
IGI: Inferred from genetic interaction
27378374 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
27378374 MGI
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
34021139 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
12950080 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
34021139 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12950080 MGI
is active in postsynaptic cytosol IDA
IDA: Inferred from direct assay
34021139 MGI
is active in presynaptic cytosol IDA
IDA: Inferred from direct assay
34021139 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

RNA-binding protein FUS

  • fusion, derived from t(12

  • 16) malignant liposarcoma

  • hnRNP P2

  • pigpen protein

  • protein pigpen

  • translocated in liposarcoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-147410 Ulefnersen 99.22% Phase 3

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10580 Vasculotide Activator 99.84% Unkown
HY-P10580A Vasculotide TFA Activator 99.88% Unkown
HY-147410A Ulefnersen sodium 98.47% Unkown
HY-RS05149 FUS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17359 Fus Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23813 Fus Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fus NCBI NCBI:2521