SEC61G - SEC61 translocon subunit gamma Gene

Also Known as SSS1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23480

About SEC61G

Cytogenetic location: 7p11.2 Genomic coordinates (GRCh38): 7:54,752,253-54,759,211 (from NCBI)

This gene has 7 transcripts (splice variants) and 250 orthologues. Ubiquitous expression in colon (RPKM 71.5), prostate (RPKM 56.4) and 25 other tissues.

Summary

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the gamma-subunit protein. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

SEC61G Products (2)

mRNA Protein Name
NM_001012456.2 NP_001012474.1 protein transport protein Sec61 subunit gamma
NM_014302.4 NP_055117.1 protein transport protein Sec61 subunit gamma

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables ribosome binding IDA
IDA: Inferred from direct assay
32820719 GOA
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
22375059 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SEC61G Protein Structure

SecE

SecE: SecE/Sec61-gamma subunits of protein translocation complex (12 - 66)

  • 0
  • 68 a.a.
Protein Preferred Names Protein Names

protein transport protein Sec61 subunit gamma

  • SEC61 translocon gamma subunit

SEC61G Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SEC61G P60059 SFTPC Homo sapiens P11686
Y2H Array
25416956
Intra
SEC61G P60059 SFTPC Homo sapiens P11686
Y2H Prey Pooling
25416956
Intra
SEC61G P60059 LRRC25 Homo sapiens Q8N386
Y2H Prey Pooling
32296183
Intra
SEC61G P60059 LRRC25 Homo sapiens Q8N386
Validated Y2H
32296183
Intra
SEC61G P60059 LRRC25 Homo sapiens Q8N386
Y2H Array
32296183
Intra
SEC61G P60059 LCN2 Homo sapiens P80188
Y2H Prey Pooling
32296183
Intra
SEC61G P60059 LCN2 Homo sapiens P80188
Validated Y2H
32296183
Intra
SEC61G P60059 LCN2 Homo sapiens P80188
Y2H Array
32296183
Intra
SEC61G P60059 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
SEC61G P60059 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra
SEC61G P60059 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
SEC61G P60059 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
SEC61G P60059 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
Intra
SEC61G P60059 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
SEC61G P60059 PEX12 Homo sapiens O00623
Y2H Array
32296183
Intra
SEC61G P60059 PEX12 Homo sapiens O00623
Y2H Prey Pooling
32296183
Intra
SEC61G P60059 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
SEC61G P60059 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
SEC61G P60059 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
SEC61G P60059 TMEM51 Homo sapiens Q9NW97
Validated Y2H
32296183
Intra
SEC61G P60059 TMEM51 Homo sapiens Q9NW97
Y2H Array
32296183
Intra
SEC61G P60059 TMEM51 Homo sapiens Q9NW97
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Childhood Ependymoma
Autosomal Dominant Severe Congenital Neutropenia

  • Severe Congenital Neutropenia Autosomal Dominant

  • Neutropenia, Congenital, Severe, Autosomal Dominant
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12623 SEC61G Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus SEC61G VGNC VGNC:49154
Mus musculus SEC61G MGD MGI:1202066
Rattus norvegicus SEC61G RGD RGD:1596170
Macaca mulatta SEC61G VGNC VGNC:108436
Canis familiaris SEC61G VGNC VGNC:49617