CBLC - Cbl proto-oncogene C Gene

Also Known as CBL-3; RNF57; CBL-SL

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23624

About CBLC

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:44,777,869-44,800,652 (from NCBI)

This gene has 3 transcripts (splice variants), 95 orthologues, 2 paralogues and is associated with 60 phenotypes. Biased expression in duodenum (RPKM 19.1), small intestine (RPKM 14.9) and 11 other tissues.

Summary

This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

CBLC Products (2)

mRNA Protein Name
NM_001130852.1 NP_001124324.1 E3 ubiquitin-protein ligase CBL-C isoform 2
NM_012116.4 NP_036248.3 E3 ubiquitin-protein ligase CBL-C isoform 1

CBLC Protein Structure

Cbl_N

Cbl_N: CBL proto-oncogene N-terminal domain 1 (14 - 145)

Cbl_N2

Cbl_N2: CBL proto-oncogene N-terminus, EF hand-like domain (148 - 232)

Cbl_N3

Cbl_N3: CBL proto-oncogene N-terminus, SH2-like domain (234 - 319)

zf-C3HC4_3

zf-C3HC4_3: Zinc finger, C3HC4 type (RING finger) (350 - 394)

  • 0
  • 100
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  • 400
  • 474 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase CBL-C

  • Cas-Br-M (murine) ecotropic retroviral transforming sequence c

CBLC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CBLC Q9ULV8 UBE2K Homo sapiens P61086
Y2H Array
32814053
Intra
CBLC Q9ULV8 UBE2K Homo sapiens P61086
Validated Y2H
32814053
Intra
CBLC Q9ULV8 UBE2K Homo sapiens P61086
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CBLC Proteins

Cat. No. Product Name Accession Purity
HY-P74343 CBLC Protein, Human (sf9, His-GST) AAH28915.1 (M1-A474) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B2209 Hydroxocobalamin 99.32% Yes

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-107643 Reversan Inhibitor 99.57% Unkown
HY-154992 2,4-Difluorophenylethynylcobalamin 98.97% Unkown
HY-124922 CBLC100 / Unkown
HY-RS01998 CBLC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08509 MMACHC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19579 Cblc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26076 Cblc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CBLC VGNC VGNC:108489
Felis catus CBLC VGNC VGNC:60422
Rattus norvegicus CBLC RGD RGD:1307651
Canis familiaris CBLC VGNC VGNC:38760
Bos taurus CBLC VGNC VGNC:26810
Mus musculus CBLC MGD MGI:1931457
Others CBLC NCBI