Mapk7 - mitogen-activated protein kinase 7 Gene

Also Known as BMK1; ERK5; BMK-1; ERK-5; PRKM7; Erk5-T; b2b2346Clo

Species: Mus musculus

Gene Type: protein coding
Gene ID: 23939

About Mapk7

Chromosome 11: 61,379,638-61,385,232 reverse strand.GRCm39:CM001004.3

This gene has 14 transcripts (splice variants), 193 orthologues, 19 paralogues and is associated with 50 phenotypes. Ubiquitous expression in limb E14.5 (RPKM 31.7), whole brain E14.5 (RPKM 29.9) and 27 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in protein phosphorylation. Acts upstream of or within several processes, including negative regulation of intracellular signal transduction; peptidyl-serine phosphorylation; and regulation of angiogenesis. Located in cytosol and nucleus. Is expressed in several structures, including cardiovascular system; early conceptus; ganglia; genitourinary system; and salivary gland. Orthologous to human MAPK7 (mitogen-activated protein kinase 7). [provided by Alliance of Genome Resources, Apr 2022]

Mapk7 Products (7)

mRNA Protein Name
NM_011841.2 NP_035971.1 mitogen-activated protein kinase 7 isoform a
NM_001361989.1 NP_001348918.1 mitogen-activated protein kinase 7 isoform c
NM_001291036.1 NP_001277965.1 mitogen-activated protein kinase 7 isoform c
NM_001291034.1 NP_001277963.1 mitogen-activated protein kinase 7 isoform a
NM_001291035.1 NP_001277964.1 mitogen-activated protein kinase 7 isoform c
NM_001291037.1 NP_001277966.1 mitogen-activated protein kinase 7 isoform d
NM_001291033.1 NP_001277962.1 mitogen-activated protein kinase 7 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14515274 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
14515274 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
18347059 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of calcineurin-NFAT signaling cascade IMP
IMP: Inferred from mutant phenotype
18347059 MGI
acts upstream of or within negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
14675480 MGI
acts upstream of or within negative regulation of calcineurin-NFAT signaling cascade IMP
IMP: Inferred from mutant phenotype
18347059 MGI
acts upstream of or within peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
18347059 MGI
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
14515274 MGI
acts upstream of or within regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
12221099 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
18347059 MGI
located in nucleus IDA
IDA: Inferred from direct assay
18347059 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mapk7 Protein Structure

STKc_ERK5

STKc_ERK5: cd07855 (48 - 383)

  • 0
  • 200
  • 400
  • 600
  • 806 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase 7

  • MAPK 7

  • big MAP kinase 1

  • extracellular signal-regulated kinase 5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-148061 DB1113 99.86% Unkown
HY-148063 DB0614 96.07% Unkown
HY-149412 MHJ-627 Inhibitor / Unkown
HY-RS08118 MAPK7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08119 Mapk7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08120 MAPK7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mapk7 NCBI NCBI:5598