Serpine1 - serpin family E member 1 Gene

Also Known as Pai1; PAI1A; Planh; Pai1aa; RATPAI1A

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24617

About Serpine1

Primary_assembly 12: 19,601,272-19,611,657 forward strand.mRatBN7.2:CM026985.1

This gene has 1 transcript (splice variant), 187 orthologues, 49 paralogues and is associated with 150 phenotypes. Biased expression in Heart (RPKM 85.5), Adrenal (RPKM 58.3) and 8 other tissues.

Summary

Enables protease binding activity and serine-type endopeptidase inhibitor activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to hormone stimulus; and cellular response to organonitrogen compound. Located in chromaffin granule and extracellular space. Used to study several diseases, including artery disease (multiple); cerebrovascular disease (multiple); diabetes mellitus (multiple); end stage renal disease; and renal fibrosis. Biomarker of several diseases, including acute necrotizing pancreatitis; glomerulosclerosis (multiple); lung disease (multiple); middle cerebral artery infarction; and muscular atrophy. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetic retinopathy (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human SERPINE1 (Serpin family E member 1). [provided by Alliance of Genome Resources, Apr 2022]

Serpine1 Products (1)

mRNA Protein Name
NM_012620.2 NP_036752.2 plasminogen activator inhibitor 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protease binding IDA
IDA: Inferred from direct assay
9316343 RGD
enables serine-type endopeptidase inhibitor activity IDA
IDA: Inferred from direct assay
9316343 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to ATP IEP
IEP: Inferred from expression pattern
10712415 RGD
involved in cellular response to aldosterone IEP
IEP: Inferred from expression pattern
26617694 RGD
involved in cellular response to angiotensin IEP
IEP: Inferred from expression pattern
19051364 RGD
involved in cellular response to cAMP IEP
IEP: Inferred from expression pattern
9603932 RGD
involved in cellular response to cGMP IEP
IEP: Inferred from expression pattern
9812917 RGD
involved in cellular response to cycloheximide IEP
IEP: Inferred from expression pattern
9798919 RGD
involved in cellular response to dexamethasone stimulus IEP
IEP: Inferred from expression pattern
1333984 RGD
involved in cellular response to fibroblast growth factor stimulus IEP
IEP: Inferred from expression pattern
10615432 RGD
involved in cellular response to follicle-stimulating hormone stimulus IEP
IEP: Inferred from expression pattern
9716558 RGD
involved in cellular response to glucagon stimulus IEP
IEP: Inferred from expression pattern
17721610 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
15828931 RGD
involved in cellular response to gravity IEP
IEP: Inferred from expression pattern
19574431 RGD
involved in cellular response to growth factor stimulus IEP
IEP: Inferred from expression pattern
17474984 RGD
involved in cellular response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
12409145 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
10590062 RGD
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
10590062 RGD
involved in cellular response to interleukin-1 IDA
IDA: Inferred from direct assay
9420877 RGD
involved in cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
2170427 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
20060032 RGD
involved in cellular response to low-density lipoprotein particle stimulus IEP
IEP: Inferred from expression pattern
11057874 RGD
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
20054150 RGD
involved in cellular response to metal ion IEP
IEP: Inferred from expression pattern
21596853 RGD
involved in cellular response to nerve growth factor stimulus IEP
IEP: Inferred from expression pattern
21596853 RGD
involved in cellular response to nicotine IEP
IEP: Inferred from expression pattern
21596853 RGD
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
15961275 RGD
involved in cellular response to platelet-derived growth factor stimulus IEP
IEP: Inferred from expression pattern
10615432 RGD
involved in cellular response to potassium ion IEP
IEP: Inferred from expression pattern
21596853 RGD
involved in cellular response to resveratrol IEP
IEP: Inferred from expression pattern
25850408 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
19247458 RGD
involved in cellular response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
23378038 RGD
involved in decidualization IEP
IEP: Inferred from expression pattern
8862764 RGD
involved in female gonad development IDA
IDA: Inferred from direct assay
8527517 RGD
involved in mast cell activation IEP
IEP: Inferred from expression pattern
15961275 RGD
involved in negative regulation of cell migration IDA
IDA: Inferred from direct assay
15596522 RGD
involved in negative regulation of cell migration IMP
IMP: Inferred from mutant phenotype
15596522 RGD
involved in negative regulation of endopeptidase activity IDA
IDA: Inferred from direct assay
10717410 RGD
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
22659625 RGD
involved in positive regulation of calcium ion import IMP
IMP: Inferred from mutant phenotype
22659625 RGD
involved in positive regulation of coagulation IMP
IMP: Inferred from mutant phenotype
18239154 RGD
involved in positive regulation of collagen biosynthetic process IMP
IMP: Inferred from mutant phenotype
15828931 RGD
involved in positive regulation of epithelium regeneration IMP
IMP: Inferred from mutant phenotype
17071586 RGD
involved in positive regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
22659625 RGD
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
22659625 RGD
involved in positive regulation of keratinocyte migration IMP
IMP: Inferred from mutant phenotype
15174100 RGD
involved in positive regulation of receptor-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
8626514 RGD
involved in response to cytokine IEP
IEP: Inferred from expression pattern
20083474 RGD
involved in response to epidermal growth factor IEP
IEP: Inferred from expression pattern
1333984 RGD
involved in response to estrogen IEP
IEP: Inferred from expression pattern
20838740 RGD
involved in response to hyperoxia IEP
IEP: Inferred from expression pattern
19099788 RGD
involved in response to laminar fluid shear stress IEP
IEP: Inferred from expression pattern
16500919 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
9569197 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
26879937 RGD
involved in response to reactive oxygen species IEP
IEP: Inferred from expression pattern
12719791 RGD
involved in response to starvation IEP
IEP: Inferred from expression pattern
17721610 RGD
involved in response to transforming growth factor beta IEP
IEP: Inferred from expression pattern
16105028 RGD
involved in tissue regeneration IEP
IEP: Inferred from expression pattern
12399226 RGD
Cellular Component GO Annotation Evidence References Source
located in chromaffin granule IDA
IDA: Inferred from direct assay
21596853 RGD
located in extracellular region IDA
IDA: Inferred from direct assay
10717410 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
20083474 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Serpine1 Protein Structure

serpin

serpin: cl38926 (28 - 401)

  • 0
  • 100
  • 200
  • 300
  • 402 a.a.
Protein Preferred Names Protein Names

plasminogen activator inhibitor 1

  • PAI

  • PAI-1

  • endothelial plasminogen activator inhibitor

  • serine (or cysteine) peptidase inhibitor, clade E, member 1

  • serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

  • serine (or cysteine) proteinase inhibitor, clade E, member 1

  • serine (or cysteine) proteinase inhibitor, member 1

  • serpin E1

  • serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

Recombinant Serpine1 Proteins

Cat. No. Product Name Accession Purity
HY-P73336 Serpin E1 Protein, Rat (HEK293, Fc) P20961 (M1-P402) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P73655 Serpin E1 Protein, Rat (HEK293, His) NP_036752.1 (S24-P402) ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-14759 Aleplasinin 99.59% Phase 1

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12720 SERPINE1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-183583 HIF-2α-IN-18 Inhibitor / Unkown
HY-RS12721 Serpine1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12722 Serpine1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990504 Anti-SERPINE1 Antibody Inhibitor ≥99.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Serpine1 NCBI NCBI:5054