2. Gene
  3. Serpine1 - serpin family E member 1 Gene

Serpine1 - serpin family E member 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Pai1; PAI1A; Planh; Pai1aa; RATPAI1A

Gene ID: 24617 | Gene type: protein coding

About Serpine1

Primary_assembly 12: 19,601,272-19,611,657 forward strand.mRatBN7.2:CM026985.1

This gene has 1 transcript (splice variant), 187 orthologues, 49 paralogues and is associated with 150 phenotypes. Biased expression in Heart (RPKM 85.5), Adrenal (RPKM 58.3) and 8 other tissues.

Summary

Enables protease binding activity and serine-type endopeptidase inhibitor activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to hormone stimulus; and cellular response to organonitrogen compound. Located in chromaffin granule and extracellular space. Used to study several diseases, including artery disease (multiple); cerebrovascular disease (multiple); diabetes mellitus (multiple); end stage renal disease; and renal fibrosis. Biomarker of several diseases, including acute necrotizing pancreatitis; glomerulosclerosis (multiple); lung disease (multiple); middle cerebral artery infarction; and muscular atrophy. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetic retinopathy (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human SERPINE1 (serpin family E member 1). [provided by Alliance of Genome Resources, Apr 2022]

Serpine1 Products(1)

mRNA Protein Name
NM_012620.2 NP_036752.2 plasminogen activator inhibitor 1 precursor

Serpine1 Protein Structure

serpin

serpin: cl38926 (28 - 401)

  • 0
  • 100
  • 200
  • 300
  • 402 a.a.
Protein Preferred Names Protein Names

plasminogen activator inhibitor 1

PAI

PAI-1

endothelial plasminogen activator inhibitor

serine (or cysteine) peptidase inhibitor, clade E, member 1

serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

serine (or cysteine) proteinase inhibitor, clade E, member 1

serine (or cysteine) proteinase inhibitor, member 1

serpin E1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

Recombinant Serpine1 Proteins

Cat. No. Product Name Accession Purity
HY-P73336 Serpin E1 Protein, Rat (HEK293, Fc) P20961 (M1-P402) ≥95%
HY-P73655 Serpin E1 Protein, Rat (HEK293, His) NP_036752.1 (S24-P402) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12720 SERPINE1 Human Pre-designed siRNA Set A / Unkown
HY-RS12721 Serpine1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS12722 Serpine1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Serpine1 NCBI NCBI:5054