Pomc - proopiomelanocortin Gene

Also Known as Pomc1; Pomc2; alphaMSH

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24664

Summary

Predicted to enable hormone activity and Melanocortin Receptor binding activity. Predicted to be involved in several processes, including cortisol secretion; positive regulation of cAMP-mediated signaling; and regulation of gene expression. Predicted to act upstream of or within several processes, including calcium-mediated signaling; glucose homeostasis; and regulation of glycogen metabolic process. Located in extracellular region. Human ortholog(s) of this gene implicated in familial Mediterranean fever; obesity; and osteoarthritis. Orthologous to human POMC (proopiomelanocortin). [provided by Alliance of Genome Resources, Apr 2022]

Pomc Products (1)

mRNA Protein Name
NM_139326.3 NP_647542.1 pro-opiomelanocortin precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in response to alcohol IEP
IEP: Inferred from expression pattern
16925589 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
28511993 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
15316242 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pro-opiomelanocortin

  • alpha-melanocyte-stimulating hormone

  • corticotropin-lipotropin

  • pro-opiomelanocortin-alpha

  • proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin)

  • proopiomelan

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-P0252 α-MSH Agonist 99.98% Phase 2
HY-N6733 Aphidicolin 99.93% Phase 1

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P0252A α-MSH TFA Agonist 98.97% Unkown
HY-P2281A Atrial natriuretic factor (1-28) (human, porcine) TFA 98.23% Unkown
HY-P1210A Lys-γ3-MSH(human) TFA 97.44% Unkown
HY-P1922 γ-2-MSH (41-58), amide Agonist 98.16% Unkown
HY-P2281 Atrial natriuretic factor (1-28) (human, porcine) / Unkown
HY-117787 TUG-905 Agonist / Unkown
HY-121859 RU28362 / Unkown
HY-N18367 Lemairamin / Unkown
HY-P1210 Lys-γ3-MSH(human) Agonist / Unkown
HY-P4779 Acetyl-ACTH (2-24) (human, bovine, rat) Modulator / Unkown
HY-P4782 Acetyl-ACTH (3-24) (human, bovine, rat) Modulator / Unkown
HY-P4784 Acetyl-ACTH (4-24) (human, bovine, rat) Modulator / Unkown
HY-P4786 Acetyl-ACTH (7-24) (human, bovine, rat) / Unkown
HY-P4985 γ3-MSH / Unkown
HY-RS10865 POMC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17248 Pomc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23702 Pomc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pomc NCBI NCBI:5443