Esr1 - estrogen receptor 1 Gene

Also Known as Esr; ER-alpha; RNESTROR

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24890

About Esr1

Primary_assembly 1: 41,210,475-41,495,002 forward strand.mRatBN7.2:CM026974.1

This gene has 10 transcripts (splice variants), 212 orthologues, 8 paralogues and is associated with 104 phenotypes. Biased expression in Uterus (RPKM 235.5), Kidney (RPKM 77.3) and 7 other tissues.

Summary

Enables several functions, including phosphatidylinositol 3-kinase regulatory subunit binding activity; promoter-specific chromatin binding activity; and transcription coactivator binding activity. Involved in several processes, including cellular response to lipid; regulation of neuron death; and reproductive structure development. Located in several cellular components, including T-tubule; perikaryon; and perinuclear region of cytoplasm. Part of protein-containing complex. Used to study several diseases, including Parkinsonism; infertility; obesity; pleurisy; and prostate disease (multiple). Biomarker of cryptorchidism; osteoporosis; and ovarian Cancer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bone disease (multiple); breast Cancer (multiple); type 2 diabetes mellitus; and vitiligo. Orthologous to human ESR1 (Estrogen receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Esr1 Products (1)

mRNA Protein Name
NM_012689.1 NP_036821.1 estrogen receptor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IMP
IMP: Inferred from mutant phenotype
12372009 RGD
enables enzyme binding IPI
IPI: Inferred from physical interaction
19422801 RGD
enables hormone binding IDA
IDA: Inferred from direct assay
17928626 RGD
enables hormone binding IMP
IMP: Inferred from mutant phenotype
15105439 RGD
enables nuclear steroid receptor activity IDA
IDA: Inferred from direct assay
17928626 RGD
enables phosphatidylinositol 3-kinase regulatory subunit binding IPI
IPI: Inferred from physical interaction
16971528 RGD
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
24046281 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11818503 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
18434427 RGD
enables steroid binding IDA
IDA: Inferred from direct assay
15705806 RGD
enables transcription coactivator binding IPI
IPI: Inferred from physical interaction
18511507 RGD
enables type 1 metabotropic glutamate receptor binding IPI
IPI: Inferred from physical interaction
18948402 RGD
Biological Process GO Annotation Evidence References Source
involved in Sertoli cell development IEP
IEP: Inferred from expression pattern
24056172 RGD
involved in Sertoli cell proliferation IMP
IMP: Inferred from mutant phenotype
17928626 RGD
involved in baculum development IEP
IEP: Inferred from expression pattern
21471296 RGD
involved in cellular response to estradiol stimulus IDA
IDA: Inferred from direct assay
15705806 RGD
involved in cellular response to estrogen stimulus IEP
IEP: Inferred from expression pattern
17272396 RGD
involved in cellular response to wortmannin IEP
IEP: Inferred from expression pattern
17272396 RGD
involved in decidualization IEP
IEP: Inferred from expression pattern
21248290 RGD
involved in male gonad development IEP
IEP: Inferred from expression pattern
20951417 RGD
involved in negative regulation of D-glucose import IDA
IDA: Inferred from direct assay
23871901 RGD
involved in negative regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
15126114 RGD
involved in negative regulation of smooth muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
21808025 RGD
involved in negative regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
22099601 RGD
involved in negative regulation of triglyceride metabolic process IDA
IDA: Inferred from direct assay
23871901 RGD
involved in nuclear receptor-mediated steroid hormone signaling pathway IDA
IDA: Inferred from direct assay
15705806 RGD
involved in osteoblast development IEP
IEP: Inferred from expression pattern
9528993 RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
15705806 RGD
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
17928626 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
15705806 RGD
involved in positive regulation of epidermal growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17928626 RGD
involved in positive regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
25004094 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
9528993 RGD
Cellular Component GO Annotation Evidence References Source
located in T-tubule IDA
IDA: Inferred from direct assay
16876190 RGD
located in nucleus IDA
IDA: Inferred from direct assay
15705806 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
16122717 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
17928626 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
18434427 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
17314305 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Esr1 Protein Structure

Oest_recep

Oest_recep: pfam02159 (74 - 218)

NR_DBD_ER

NR_DBD_ER: cd07171 (217 - 298)

NR_LBD_ER

NR_LBD_ER: cd06949 (347 - 616)

ESR1_C

ESR1_C: cl15062 (621 - 664)

  • 0
  • 200
  • 400
  • 600
  • 665 a.a.
Protein Preferred Names Protein Names

estrogen receptor

  • C-terminally-truncated estrogen receptor alpha product-1

  • Er alpha

  • estradiol receptor

  • estrogen receptor 1 (alpha)

  • estrogen receptor alpha i45aL

  • estrogen receptor alpha i45aS

  • estrogen receptor alpha i45c

  • estrogen receptor alpha i56a

  • estrogen receptor alpha i56b

  • estrogen receptor alpha i56c

  • estrogen receptor alpha i56dL

  • estrogen receptor alpha i56dS

  • estrogen receptor alpha i56e

  • estrogen receptor alpha variant delta 4

  • estrogen receptor protein

  • nuclear receptor subfamily 3 group A member 1

  • trunctaed

Esr1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Esr1 P06211 Rps27a Rattus norvegicus P62989
Anti Bait CoIP
21808025
Intra
Esr1 P06211 St13 Rattus norvegicus P50503
Anti Bait CoIP
21808025
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-136255 Camizestrant Inhibitor 99.32% Phase 3

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-147165 VT02956 Inhibitor 99.58% Unkown
HY-21191 Perfluorobutanesulfonic acid 98.0% Unkown
HY-N1508 Ecliptasaponin A 99.81% Unkown
HY-163650 DTPD-Q 99.68% Unkown
HY-125236 ZEN-3694 99.85% Unkown
HY-149480 ERD-3111 Degrader 98.72% Unkown
HY-RS04529 ESR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04530 Esr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-101119 GLL398 Degrader / Unkown
HY-147165A VT02956 hydrochloride Inhibitor / Unkown
HY-164924 ERD-12310A Degrader / Unkown
HY-183319 Anticancer agent 320 / Unkown
HY-183804 PROTAC ER Degrader-16 Degrader / Unkown
HY-21191S Perfluorobutanesulfonic acid-13C3 sodium / Unkown
HY-N17632 Moracin G / Unkown
HY-N18209 4-Hydroxy-3-butylphthalide / Unkown
HY-RS04531 Esr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Esr1 NCBI NCBI:2099