2. Gene
  3. Esr1 - estrogen receptor 1 Gene

Esr1 - estrogen receptor 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Esr; ER-alpha; RNESTROR

Gene ID: 24890 | Gene type: protein coding

About Esr1

Primary_assembly 1: 41,210,475-41,495,002 forward strand.mRatBN7.2:CM026974.1

This gene has 10 transcripts (splice variants), 212 orthologues, 8 paralogues and is associated with 104 phenotypes. Biased expression in Uterus (RPKM 235.5), Kidney (RPKM 77.3) and 7 other tissues.

Summary

Enables several functions, including phosphatidylinositol 3-kinase regulatory subunit binding activity; promoter-specific chromatin binding activity; and transcription coactivator binding activity. Involved in several processes, including cellular response to lipid; regulation of neuron death; and reproductive structure development. Located in several cellular components, including T-tubule; perikaryon; and perinuclear region of cytoplasm. Part of protein-containing complex. Used to study several diseases, including Parkinsonism; infertility; obesity; pleurisy; and prostate disease (multiple). Biomarker of cryptorchidism; osteoporosis; and ovarian Cancer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); bone disease (multiple); breast Cancer (multiple); type 2 diabetes mellitus; and vitiligo. Orthologous to human ESR1 (Estrogen Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Esr1 Products(1)

mRNA Protein Name
NM_012689.1 NP_036821.1 estrogen receptor

Esr1 Protein Structure

Oest_recep

Oest_recep: pfam02159 (74 - 218)

NR_DBD_ER

NR_DBD_ER: cd07171 (217 - 298)

NR_LBD_ER

NR_LBD_ER: cd06949 (347 - 616)

ESR1_C

ESR1_C: cl15062 (621 - 664)

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  • 665 a.a.
Protein Preferred Names Protein Names

estrogen receptor

C-terminally-truncated estrogen receptor alpha product-1

Er alpha

estradiol receptor

estrogen receptor 1 (alpha)

estrogen receptor alpha i45aL

estrogen receptor alpha i45aS

estrogen receptor alpha i45c

estrogen receptor alpha i56a

estrogen receptor alpha i56b

estrogen receptor alpha i56c

estrogen receptor alpha i56dL

estrogen receptor alpha i56dS

estrogen receptor alpha i56e

estrogen receptor alpha variant delta 4

estrogen receptor protein

nuclear receptor subfamily 3 group A member 1

trunctaed

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-136255 Camizestrant Inhibitor 98.04% Phase 3
Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-147165 VT02956 Inhibitor 99.58% Unkown
HY-149480 ERD-3111 Degrader / Unkown
HY-RS04529 ESR1 Human Pre-designed siRNA Set A / Unkown
HY-RS04530 Esr1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS04531 Esr1 Rat Pre-designed siRNA Set A / Unkown
HY-147165A VT02956 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Esr1 NCBI NCBI:2099